A hybrid IRF9-STAT2 protein recapitulates interferon-stimulated gene expression and antiviral response. - Wikidata - awgldk - TriplyDB

A hybrid IRF9-STAT2 protein recapitulates interferon-stimulated gene expression and antiviral response.

A hybrid IRF9-STAT2 protein recapitulates interferon-stimulated gene expression and antiviral response.

http://www.wikidata.org/entity/Q38357901

about

Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway The IRF family, revisited IRF7-dependent type I interferon production induces lethal immune-mediated disease in STAT1 knockout mice infected with lymphocytic choriomeningitis virus.Intracellular expression of IRF9 Stat fusion protein overcomes the defective Jak-Stat signaling and inhibits HCV RNA replication.Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1.Mind-controlled transgene expression by a wireless-powered optogenetic designer cell implant.Chromatin dynamics of gene activation and repression in response to interferon alpha (IFN(alpha)) reveal new roles for phosphorylated and unphosphorylated forms of the transcription factor STAT2 Proof of concept study to assess fetal gene expression in amniotic fluid by nanoarray PCR STAT2/IRF9 directs a prolonged ISGF3-like transcriptional response and antiviral activity in the absence of STAT1.Variation in the Ovine Abomasal Lymph Node Transcriptome between Breeds Known to Differ in Resistance to the Gastrointestinal Nematode Activation of Oas1a gene expression by type I IFN requires both STAT1 and STAT2 while only STAT2 is required for Oas1b activation.Type 1 IFN-independent activation of a subset of interferon stimulated genes in West Nile virus Eg101-infected mouse cells.Mouse STAT2 restricts early dengue virus replication A RIG-I 2CARD-MAVS200 Chimeric Protein Reconstitutes IFN-β Induction and Antiviral Response in Models Deficient in Type I IFN Response.STAT2-dependent induction of RNA adenosine deaminase ADAR1 by type I interferon differs between mouse and human cells in the requirement for STAT1 Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2 Respiratory Syncytial Virus Persistence in Murine Macrophages Impairs IFN-β Response but Not Synthesis.Interferon regulatory factor 9 protects against hepatic insulin resistance and steatosis in male mice The tiers and dimensions of evasion of the type I interferon response by human cytomegalovirus.Novel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1.STAT2 and IRF9: Beyond ISGF3.Interferon-Stimulated Genes Are Transcriptionally Repressed by PR in Breast Cancer.IRF9-Stat2 Fusion Protein as an Innate Immune Inducer to Activate Mx and Interferon-Stimulated Gene Expression in Zebrafish Larvae.Canonical and Non-Canonical Aspects of JAK-STAT Signaling: Lessons from Interferons for Cytokine Responses.IFNβ/TNFα synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH oxidase-mediated airway antiviral response.The molecular basis for differential type I interferon signaling.The Epstein-Barr virus-encoded LMP-1 oncoprotein negatively affects Tyk2 phosphorylation and interferon signaling in human B cells.STAT1 is essential for the inhibition of hepatitis C virus replication by interferon-λ but not by interferon-α.STAT2 nuclear trafficking.Cells previously desensitized to type 1 interferons display different mechanisms of activation of stat-dependent gene expression from naïve cells.Structural basis of STAT2 recognition by IRF9 reveals molecular insights into ISGF3 function.A Positive Feedback Amplifier Circuit That Regulates Interferon (IFN)-Stimulated Gene Expression and Controls Type I and Type II IFN Responses.Interferon regulatory factor 1 inactivation in human cancer.The Effect of SH2B1 Variants on Expression of Leptin- and Insulin-Induced Pathways in Murine Hypothalamus.Interferon Regulatory Factor 9 Structure and Regulation

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A hybrid IRF9-STAT2 protein recapitulates interferon-stimulated gene expression and antiviral response.

http://www.wikidata.org/entity/Q38357901

description

2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

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2003年學術文章

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2003年學術文章

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name

A hybrid IRF9-STAT2 protein re ...... ession and antiviral response.

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type

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A hybrid IRF9-STAT2 protein re ...... ession and antiviral response.

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A hybrid IRF9-STAT2 protein re ...... ession and antiviral response.

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P1433

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Journal of Biological Chemistry

P1476

A hybrid IRF9-STAT2 protein re ...... ession and antiviral response.

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P2093

Curt M Horvath

http://www.w3.org/2001/XMLSchema#string

Jean-Patrick Parisien

http://www.w3.org/2001/XMLSchema#string

Joe F Lau

http://www.w3.org/2001/XMLSchema#string

Thomas A Kraus

http://www.w3.org/2001/XMLSchema#string

P2860

Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA

Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7

Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation.

Antiviral actions of interferons

Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes

Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex

Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors

Stat protein transactivation domains recruit p300/CBP through widely divergent sequences

Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3

Inhibition of PKR activation by the proline-rich RNA binding domain of the herpes simplex virus type 1 Us11 protein.

P304

13033-13038

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scholarly article

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10.1074/JBC.M212972200

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15

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278

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2003-02-05T00:00:00Z

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12574168

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