Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma ) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity.
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PPAR-γ agonists and their effects on IGF-I receptor signaling: Implications for cancerNAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathwayThe non-genomic crosstalk between PPAR-gamma ligands and ERK1/2 in cancer cell linesPeroxisome proliferator-activated receptor gamma overexpression inhibits pro-fibrogenic activities of immortalised rat pancreatic stellate cellsDependence of peroxisome proliferator-activated receptor ligand-induced mitogen-activated protein kinase signaling on epidermal growth factor receptor transactivationRegulation of Lhb and Egr1 gene expression by GNRH pulses in rat pituitaries is both c-Jun N-terminal kinase (JNK)- and extracellular signal-regulated kinase (ERK)-dependent.PPARgamma-independent induction of growth arrest and apoptosis in prostate and bladder carcinomaPeroxisome proliferator-activated receptor gamma-dependent activity of indole ring-substituted 1,1-bis(3'-indolyl)-1-(p-biphenyl)methanes in cancer cells.The peroxisome proliferator-activated receptor gamma system regulates ultraviolet B-induced prostaglandin e(2) production in human epidermal keratinocytes.MCC-555-induced NAG-1 expression is mediated in part by KLF4.A transcriptional signaling pathway in the IFN system mediated by 2'-5'-oligoadenylate activation of RNase L.Adenovirus 5 E1A enhances histone deacetylase inhibitors-induced apoptosis through Egr-1-mediated Bim upregulationNegative regulation of the oncogenic transcription factor FoxM1 by thiazolidinediones and mithramycin.Cold-shock-domain protein A (CSDA) contributes posttranscriptionally to gonadotropin-releasing hormone-regulated expression of Egr1 and indirectly to Lhb.Two in-and-out modulation strategies for endoplasmic reticulum stress-linked gene expression of pro-apoptotic macrophage-inhibitory cytokine 1.Intrahepatic expression of genes related to metabotropic receptors in chronic hepatitis.A peroxisome proliferator-activated receptor ligand MCC-555 imparts anti-proliferative response in pancreatic cancer cells by PPARgamma-independent up-regulation of KLF4.Molecular characterisation of canine nonsteroidal anti-inflammatory drug-activated gene (NAG-1).The diverse roles of nonsteroidal anti-inflammatory drug activated gene (NAG-1/GDF15) in cancer.A Role for the PPARgamma in Cancer Therapy.PPARgamma and Apoptosis in Cancer.A Novel Mechanism of PPARgamma Regulation of TGFbeta1: Implication in Cancer BiologyRegulation of EP4 expression via the Sp-1 transcription factor: inhibition of expression by anti-cancer agentsCharacterization of PPAR dual ligand MCC-555 in AOM-induced colorectal tumorigenesis.Gene alterations by peroxisome proliferator-activated receptor gamma agonists in human colorectal cancer cellsRosiglitazone Suppresses the Growth and Invasiveness of SGC-7901 Gastric Cancer Cells and Angiogenesis In Vitro via PPARgamma Dependent and Independent MechanismsPeroxisome proliferator-activated receptor-delta induces cell proliferation by a cyclin E1-dependent mechanism and is up-regulated in thyroid tumorsPeroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in ApcMin/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathwaysESE-1/EGR-1 pathway plays a role in tolfenamic acid-induced apoptosis in colorectal cancer cells.Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cellsThe role of peroxisome proliferator-activated receptor γ in pancreatic β cell function and survival: therapeutic implications for the treatment of type 2 diabetes mellitus.The Role of PPAR Ligands in Controlling Growth-Related Gene Expression and their Interaction with Lipoperoxidation Products.Nonsteroidal anti-inflammatory drug-activated gene-1 expression inhibits urethane-induced pulmonary tumorigenesis in transgenic mice.Induction of apoptosis and nonsteroidal anti-inflammatory drug-activated gene 1 in pancreatic cancer cells by a glycyrrhetinic acid derivative.Pharmacological exploitation of the peroxisome proliferator-activated receptor gamma agonist ciglitazone to develop a novel class of androgen receptor-ablative agents.The high affinity peroxisome proliferator-activated receptor-gamma agonist RS5444 inhibits both initiation and progression of colon tumors in azoxymethane-treated mice.Current understanding of the role of PPARγ in gastrointestinal cancersPeroxisome proliferator-activated receptor γ and colorectal cancer.Functional role of peroxisome-proliferator-activated receptor γ in hepatocellular carcinoma.The early-immediate gene EGR-1 is induced by transforming growth factor-beta and mediates stimulation of collagen gene expression.
P2860
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P2860
Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma ) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Troglitazone, a peroxisome pro ...... its anti-tumorigenic activity.
@en
type
label
Troglitazone, a peroxisome pro ...... its anti-tumorigenic activity.
@en
prefLabel
Troglitazone, a peroxisome pro ...... its anti-tumorigenic activity.
@en
P2093
P2860
P356
P1476
Troglitazone, a peroxisome pro ...... its anti-tumorigenic activity
@en
P2093
Leigh C Wilson
Linda C Hsi
Thomas E Eling
P2860
P304
P356
10.1074/JBC.M208394200
P407
P577
2002-12-09T00:00:00Z