Expression of the transcription factor, Spi-1 (PU.1), in differentiating murine erythroleukemia cells Is regulated post-transcriptionally. Evidence for differential stability of transcription factor mRNAs following inducer exposure.
about
The conserved 5'-untranslated leader of Spi-1 (PU.1) mRNA is highly structured and potently inhibits translation in vitro but not in vivoSpi-1/PU.1 is a positive regulator of the Fli-1 gene involved in inhibition of erythroid differentiation in friend erythroleukemic cell linesMaking (anti)sense of non-coding sequence conservationReduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARalpha.Transcription factor Spi-B binds unique sequences present in the tandem repeat promoter/enhancer of JC virus and supports viral activitySox4 cooperates with PU.1 haploinsufficiency in murine myeloid leukemia.C/EBPalpha determines hematopoietic cell fate in multipotential progenitor cells by inhibiting erythroid differentiation and inducing myeloid differentiationSpi-1 and Fli-1 directly activate common target genes involved in ribosome biogenesis in Friend erythroleukemic cells.The carboxyl-terminal domain of the granulocyte colony-stimulating factor receptor uncouples ribosomal biogenesis from cell cycle progression in differentiating 32D myeloid cells.Role of PU.1 in hematopoiesis.Inducers of erythroleukemic differentiation cause messenger RNAs that lack poly(A)-binding protein to accumulate in translationally inactive, salt-labile 80 S ribosomal complexes.
P2860
Q24544980-05D2B41D-02C6-4375-A07F-9BB0DC308888Q24554758-4A37370B-C21F-4CC9-AB16-90C42D68A68BQ33368236-C4C12385-ACA6-456D-A1F5-9A5CC8ABEC90Q33920326-B1E10F06-BDCE-4E2C-8527-3A95D9FBE495Q34136900-38821A07-4865-4157-845D-836D94B20FD8Q35525433-C8CC1742-20ED-4F30-9AF8-9B9D1A7B3134Q35849682-398F558D-A019-47D5-ABAA-BBFCD50F416BQ37192083-2678CD6D-B9B6-44AC-8EF3-2664A6AB6C91Q40775108-163C4C06-25CD-4F73-AEBF-6FDCD278F3D5Q41706344-1317B865-B868-4E4F-A484-F0BC310CE333Q52199789-8EF9451D-4AFE-4709-ACBB-6FB6851DEF14
P2860
Expression of the transcription factor, Spi-1 (PU.1), in differentiating murine erythroleukemia cells Is regulated post-transcriptionally. Evidence for differential stability of transcription factor mRNAs following inducer exposure.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Expression of the transcriptio ...... As following inducer exposure.
@en
type
label
Expression of the transcriptio ...... As following inducer exposure.
@en
prefLabel
Expression of the transcriptio ...... As following inducer exposure.
@en
P2093
P2860
P356
P1476
Expression of the transcriptio ...... As following inducer exposure.
@en
P2093
P2860
P304
P356
10.1074/JBC.271.7.3385
P407
P577
1996-02-01T00:00:00Z