Leptin gene expression in human preadipocytes is switched on by maturation-induced demethylation of distinct CpGs in its proximal promoter.
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Ten putative contributors to the obesity epidemicEpigenetics: a molecular link between environmental factors and type 2 diabetesDNA methylation differences after exposure to prenatal famine are common and timing- and sex-specificEarly Life Nutrition and Energy Balance Disorders in Offspring in Later LifeNutrition, epigenetics, and metabolic syndromeGender Differences in Adipocyte Metabolism and Liver Cancer ProgressionChito-oligosaccharide inhibits the de-methylation of a 'CpG' island within the leptin (LEP) promoter during adipogenesis of 3T3-L1 cellsEarly life nutrition, epigenetics and programming of later life diseaseEffects of Gestational Magnetic Resonance Imaging on Methylation Status of Leptin Promoter in the Placenta and Cord BloodDynamics of adipogenic promoter DNA methylation during clonal culture of human adipose stem cells to senescence.Differential adipokine DNA methylation and gene expression in subcutaneous adipose tissue from adult offspring of women with diabetes in pregnancy.IKKβ links vascular inflammation to obesity and atherosclerosis36 h fasting of young men influences adipose tissue DNA methylation of LEP and ADIPOQ in a birth weight-dependent manner.Association of bovine leptin polymorphisms with energy output and energy storage traits in progeny tested Holstein-Friesian dairy cattle sires.Epigenetics meets endocrinology.Role of Ucp1 enhancer methylation and chromatin remodelling in the control of Ucp1 expression in murine adipose tissuePerinatal environment and its influences on metabolic programming of offspring.Leptin gene epigenetic adaptation to impaired glucose metabolism during pregnancy.Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs.The role of heredity in pterygium developmentMendelian randomization supports causality between maternal hyperglycemia and epigenetic regulation of leptin gene in newborns.Maternal obesity and gestational diabetes are associated with placental leptin DNA methylation.Excess of methyl donor in the perinatal period reduces postnatal leptin secretion in rat and interacts with the effect of protein content in dietStable CpG hypomethylation of adipogenic promoters in freshly isolated, cultured, and differentiated mesenchymal stem cells from adipose tissue.An analysis of DNA methylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight loss.The Regulation of Leptin, Leptin Receptor and Pro-opiomelanocortin Expression by N-3 PUFAs in Diet-Induced Obese Mice Is Not Related to the Methylation of Their Promoters.Maternal environment and the transgenerational cycle of obesity and diabetes.Epigenetic regulation of mesenchymal stem cells: a focus on osteogenic and adipogenic differentiation.Developmental programming of the metabolic syndrome - critical windows for intervention.Maternal obesity and developmental programming of metabolic disorders in offspring: evidence from animal models.Human leptin tissue distribution, but not weight loss-dependent change in expression, is associated with methylation of its promoter.Leptin and adiponectin DNA methylation levels in adipose tissues and blood cells are associated with BMI, waist girth and LDL-cholesterol levels in severely obese men and women.Are MTHFR C677T and MTRR A66G Polymorphisms Associated with Overweight/Obesity Risk? From a Case-Control to a Meta-Analysis of 30,327 Subjects.FOSL2 promotes leptin gene expression in human and mouse adipocytes.HIF-1A and C/EBPs transcriptionally regulate adipogenic differentiation of bone marrow-derived MSCs in hypoxia.Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention.In utero growth restriction and catch-up adipogenesis after developmental di (2-ethylhexyl) phthalate exposure cause glucose intolerance in adult male rats following a high-fat dietary challenge.Up-regulated expression and aberrant DNA methylation of LEP and SH3PXD2A in pre-eclampsia.Gene-environment interactions and epigenetic basis of human diseases.Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction.
P2860
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P2860
Leptin gene expression in human preadipocytes is switched on by maturation-induced demethylation of distinct CpGs in its proximal promoter.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Leptin gene expression in huma ...... CpGs in its proximal promoter.
@en
type
label
Leptin gene expression in huma ...... CpGs in its proximal promoter.
@en
prefLabel
Leptin gene expression in huma ...... CpGs in its proximal promoter.
@en
P2093
P356
P1476
Leptin gene expression in huma ...... CpGs in its proximal promoter.
@en
P2093
Cornelia Hasel
Ingo Melzner
Karola Dorsch
Pamela Fischer
Peter Möller
Silke Brüderlein
Vanessa Scott
P304
45420-45427
P356
10.1074/JBC.M208511200
P407
P577
2002-09-03T00:00:00Z