Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism.
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Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin- proteasome mediated mechanism.SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production.Cross-talk of membrane lipids and Alzheimer-related proteins.Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavageSphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study Protein Lipid InteractionsSphingosine-1-phosphate lyase expression in embryonic and adult murine tissuesTruth and consequences of sphingosine-1-phosphate lyase.Immunohistochemical analysis of sphingosine phosphate lyase expression during murine development.A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunity.Metabolic effects of TiO2 nanoparticles, a common component of sunscreens and cosmetics, on human keratinocytesA Phosphorylatable Sphingosine Analog Induces Airway Smooth Muscle Cytostasis and Reverses Airway Hyperresponsiveness in Experimental Asthma.Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome.Lipid metabolism in Alzheimer's diseaseResveratrol and its oligomers: modulation of sphingolipid metabolism and signaling in disease.Sphingosine kinases/sphingosine-1-phosphate and death Signalling in APP-transfected cells.Altered Sphingolipid Balance in Capillary Cerebral Amyloid Angiopathy.Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease.Sphingosine 1-phosphate lyase deficiency causes Charcot-Marie-Tooth neuropathy.Crosstalk between sphingolipids and vitamin D3: potential role in the nervous system.Identification of NCF2/p67phox as a novel p53 target geneOmega-3 fatty acids, lipids and apoE lipidation in Alzheimer's disease: a rationale for multi-nutrient dementia prevention.Implication of sphingosine-1-phosphate signaling in diseases: molecular mechanism and therapeutic strategies.Deficiency of sphingosine-1-phosphate lyase impairs lysosomal metabolism of the amyloid precursor protein.Sphingosine 1-phosphate (S1P) lyase deficiency increases sphingolipid formation via recycling at the expense of de novo biosynthesis in neuronsOverexpression of sphingosine-1-phosphate lyase protects insulin-secreting cells against cytokine toxicity.Modulation of sphingosine 1-phosphate (S1P) attenuates spatial learning and memory impairments in the valproic acid rat model of autism.Application of Metabolomics in Alzheimer's Disease.Phospholipid and Lipid Derivatives as Potential Neuroprotective Compounds
P2860
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P2860
Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Sphingosine-1-phosphate links ...... a calpain-mediated mechanism.
@en
type
label
Sphingosine-1-phosphate links ...... a calpain-mediated mechanism.
@en
prefLabel
Sphingosine-1-phosphate links ...... a calpain-mediated mechanism.
@en
P2093
P2860
P356
P1476
Sphingosine-1-phosphate links ...... a calpain-mediated mechanism.
@en
P2093
D Hartmann
D Swandulla
G van Echten-Deckert
P2860
P2888
P304
P356
10.1038/CDD.2011.7
P577
2011-02-18T00:00:00Z