The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells.
about
Effector, Memory, and Dysfunctional CD8(+) T Cell Fates in the Antitumor Immune ResponseT Cells and Gene Regulation: The Switching On and Turning Up of Genes after T Cell Receptor Stimulation in CD8 T CellsTargeting Transcriptional Regulators of CD8+ T Cell Dysfunction to Boost Anti-Tumor ImmunityNewtonian cell interactions shape natural killer cell educationMolecular and cellular insights into T cell exhaustionSignature Channels of Excitability no More: L-Type Channels in Immune CellsOvercoming T cell exhaustion in infection and cancerAdjunct Strategies for Tuberculosis Vaccines: Modulating Key Immune Cell Regulatory Mechanisms to Potentiate VaccinationInnate and Adaptive Immune Regulation During Chronic Viral InfectionsFeeding an army: The metabolism of T cells in activation, anergy, and exhaustionIL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumoursEpigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade.Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses.Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cellsDCIR2+ cDC2 DCs and Zbtb32 Restore CD4+ T-Cell Tolerance and Inhibit DiabetesNFAT2 Isoforms Differentially Regulate Gene Expression, Cell Death, and Transformation through Alternative N-Terminal Domains.Transcription factor NFAT1 controls allergic contact hypersensitivity through regulation of activation induced cell death program.PD-1 expression conditions T cell avidity within an antigen-specific repertoire.Costimulatory and Coinhibitory Receptor Pathways in Infectious DiseasePSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion.Store-Operated Ca(2+) Entry in Follicular T Cells Controls Humoral Immune Responses and AutoimmunityDissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seqImmediate Dysfunction of Vaccine-Elicited CD8+ T Cells Primed in the Absence of CD4+ T Cells.Phenotypic alteration of CD8+ T cells in chronic lymphocytic leukemia is associated with epigenetic reprogramming.Tet2 and Tet3 cooperate with B-lineage transcription factors to regulate DNA modification and chromatin accessibility.Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer.IκB Kinase ε Is an NFATc1 Kinase that Inhibits T Cell Immune ResponseCutting Edge: NFAT Transcription Factors Promote the Generation of Follicular Helper T Cells in Response to Acute Viral Infection.Control of NFAT Isoform Activation and NFAT-Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca2+ Signals.Cutting Edge: Chromatin Accessibility Programs CD8 T Cell Memory.Calcium-NFAT transcriptional signalling in T cell activation and T cell exhaustion.PSGL-1: A New Player in the Immune Checkpoint Landscape.Visualizing the life of mRNA in T cells.TET Methylcytosine Oxidases in T Cell and B Cell Development and Function.Transcriptional and epigenetic regulation of T cell hyporesponsiveness.Molecular Dissection of CD8+ T-Cell Dysfunction.NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells.NFATc1 controls the cytotoxicity of CD8+ T cells.Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory.The Transcription Factor NFAT1 Participates in the Induction of CD4+ T Cell Functional Exhaustion during Plasmodium yoelii Infection.
P2860
Q26744527-314E7C06-42EC-461C-830B-E1175907406AQ26765917-4911096E-399E-4C51-899E-F6F132BFDA86Q26782201-C86226F8-2BE4-4989-A20F-12E0F4BC86C0Q26797240-B782747F-0D56-40AA-A65A-DEEB726861FAQ26800047-BFE0DE87-CF2B-45E2-B375-32ACE2306938Q26800131-0061451F-AA3B-42EC-ABCB-136AD447B92EQ26829885-77554D18-1205-4322-902B-0B809C1D1756Q28074536-DFF4B42D-C248-4059-B118-1C55DED65B83Q28079717-F8130EF2-E334-48BD-8348-151328150BD6Q28085624-2876B952-C718-44CC-ADD6-DCF050AB80A6Q33786422-089DC9C7-5492-49E8-8BFC-EDBF560906FEQ33835454-4FE26C8A-F263-48A0-AAE7-1EDB5360842AQ34514517-5BCC3B61-A0B9-4C7A-9D83-B4FC720C878BQ35824223-E4C1BDB5-9838-4D11-9B9F-3D2C1B4BB77BQ36104619-3D9779E5-C7C2-4825-889D-9196B1B50CEFQ36434003-7555BA8A-E776-4553-A8B0-CA75AC7C47DCQ36500059-2C8D7B96-8CDF-4D2C-9175-BA36B0691FEFQ36597350-7A41FFAE-96A8-4544-A3F7-E1B47D95F0AFQ36919711-749845B1-D5DA-4E2F-8523-69DFF596933AQ37007388-467C2852-43FE-44BD-81F1-14826442CE48Q37029755-13B21336-DED7-451E-A3D9-321C9940DEF6Q37094024-F4159F58-017A-439E-A31C-D4E529C13D98Q37189696-C678A0C2-424C-4682-8087-05362D5B58D5Q37457945-D0B047C9-5F93-4FB1-841C-DF4511ED8B25Q37482137-8BACD724-6A98-4579-A1AB-F644A6AB0ADFQ37616503-436609DD-D990-46A1-8BF0-CE40D3D7567AQ37626165-C304434D-D01B-4287-B83B-C50E4487743FQ38439600-D1A2DE02-5AD3-41DF-876F-C31813C5C566Q38730315-56E82439-D1B7-4FF8-810D-7C8F0C0569C7Q38971108-3294C02C-309A-4CCF-B5A2-7D506C7CAB2FQ39116081-E05FE8CB-68DE-4A8B-9997-1B7E4042BBF5Q39163377-5630E615-200B-4631-8819-CED2D4D99F49Q39241592-BB713CB3-8316-4E66-9551-F6A588BAD028Q39241767-6A986363-667E-495F-8418-46AA6DB83D8FQ39367810-AE4076B2-3E9D-4C83-BA5A-ED8FA7A40892Q39405489-F41C8A14-9072-40D2-AA15-C51A39313491Q39738126-9D512679-4935-4A06-B67B-05B5F44B844EQ40046514-6C2DBAE2-DB9E-4E5B-B367-115D77B2A1C9Q40075894-C4DF377F-5039-4B75-823D-5A829B215D19Q40153756-A7D46BB0-F3F2-4131-88E7-AAB0447A5BF0
P2860
The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells.
@en
type
label
The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells.
@en
prefLabel
The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells.
@en
P2093
P2860
P50
P1433
P1476
The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells
@en
P2093
Anjana Rao
Edward D Lamperti
Edward Y Kim
Harri Lähdesmäki
Matthew E Pipkin
Patrick G Hogan
Shane Crotty
Susan Togher
Tarmo Äijö
Thorsten R Mempel
P2860
P304
P356
10.1016/J.IMMUNI.2015.01.006
P407
P577
2015-02-10T00:00:00Z