Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis. - Wikidata - awgldk - TriplyDB

Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis.

Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis.

http://www.wikidata.org/entity/Q38461429

about

Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros The Ikaros family of zinc-finger proteins PRMT4 is a novel coactivator of c-Myb-dependent transcription in haematopoietic cell lines Regulatory phosphorylation of Ikaros by Bruton's tyrosine kinase MBD3 localizes at promoters, gene bodies and enhancers of active genes Promoter decommissioning by the NuRD chromatin remodeling complex triggers synaptic connectivity in the mammalian brain Sall1 balances self-renewal and differentiation of renal progenitor cells A far downstream enhancer for murine Bcl11b controls its T-cell specific expression Dissecting the dynamic changes of 5-hydroxymethylcytosine in T-cell development and differentiation.β-Catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells.Epigenetic control of immunity NuRD and pluripotency: a complex balancing act.High-throughput and quantitative assessment of enhancer activity in mammals by CapStarr-seq.Diagnostic biomarkers are hidden in the infected host's epigenome.The Drosophila MI-2 chromatin-remodeling factor regulates higher-order chromatin structure and cohesin dynamics in vivo.Jarid2 is induced by TCR signalling and controls iNKT cell maturation.Constitutive function of the Ikaros transcription factor in primary leukemia cells from pediatric newly diagnosed high-risk and relapsed B-precursor ALL patients.The NuRD chromatin-remodeling enzyme CHD4 promotes embryonic vascular integrity by transcriptionally regulating extracellular matrix proteolysis.Divergent transcription is associated with promoters of transcriptional regulators.Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway.Mi-2/NuRD chromatin remodeling complexes regulate B and T-lymphocyte development and function.The IKAROS interaction with a complex including chromatin remodeling and transcription elongation activities is required for hematopoiesis.CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL.An Ikaros Promoter Element with Dual Epigenetic and Transcriptional Activities.PHF6 Degrees of Separation: The Multifaceted Roles of a Chromatin Adaptor Protein.The chromatin-remodeling enzymes BRG1 and CHD4 antagonistically regulate vascular Wnt signaling Constraint of gene expression by the chromatin remodelling protein CHD4 facilitates lineage specification.Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor.Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia.NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment.Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia.Impaired Contextual Fear Extinction Learning is Associated with Aberrant Regulation of CHD-Type Chromatin Remodeling Factors.Ikaros mediates gene silencing in T cells through Polycomb repressive complex 2.MBD2 and multiple domains of CHD4 are required for transcriptional repression by Mi-2/NuRD complexes Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia.The nucleosome remodeling and deacetylase complex in development and disease.Mi-2/NuRD is required in renal progenitor cells during embryonic kidney development.Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling

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Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis.

http://www.wikidata.org/entity/Q38461429

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

Harnessing of the nucleosome-r ...... t and prevents leukemogenesis.

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type

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Harnessing of the nucleosome-r ...... t and prevents leukemogenesis.

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Harnessing of the nucleosome-r ...... t and prevents leukemogenesis.

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Nature Immunology

P1476

Harnessing of the nucleosome-r ...... t and prevents leukemogenesis.

@en

P2093

Audrey F Jackson

http://www.w3.org/2001/XMLSchema#string

Elizabeth J Heller

http://www.w3.org/2001/XMLSchema#string

Feifei Liu

http://www.w3.org/2001/XMLSchema#string

Fotini Gounari

http://www.w3.org/2001/XMLSchema#string

Howard T Petrie

http://www.w3.org/2001/XMLSchema#string

Jiangwen Zhang

http://www.w3.org/2001/XMLSchema#string

John Seavitt

http://www.w3.org/2001/XMLSchema#string

Katia Georgopoulos

http://www.w3.org/2001/XMLSchema#string

Marei Dose

http://www.w3.org/2001/XMLSchema#string

Mariko Kashiwagi

http://www.w3.org/2001/XMLSchema#string

P2860

Model-based analysis of ChIP-Seq (MACS)

Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex

Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation

Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin

Mediator and cohesin connect gene expression and chromatin architecture

Linear models and empirical bayes methods for assessing differential expression in microarray experiments

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

The role of chromatin during transcription

Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes

A molecular dissection of the repression circuitry of Ikaros

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86-94

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10.1038/NI.2150

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1

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13

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51796245

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1051305482

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22080921

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3868219

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