Smooth muscle cell arachidonic acid release, migration, and proliferation are markedly attenuated in mice null for calcium-independent phospholipase A2beta.
about
CD36 protein is involved in store-operated calcium flux, phospholipase A2 activation, and production of prostaglandin E2Effects of endoplasmic reticulum stress on group VIA phospholipase A2 in beta cells include tyrosine phosphorylation and increased association with calnexinRole of calcium-independent phospholipase A2beta in high glucose-induced activation of RhoA, Rho kinase, and CPI-17 in cultured vascular smooth muscle cells and vascular smooth muscle hypercontractility in diabetic animals.Group VIA Ca2+-independent phospholipase A2 (iPLA2beta) and its role in beta-cell programmed cell death.iPLA2β overexpression in smooth muscle exacerbates angiotensin II-induced hypertension and vascular remodeling.Activation of group VI phospholipase A2 isoforms in cardiac endothelial cellsAnalysis of two major intracellular phospholipases A(2) (PLA(2)) in mast cells reveals crucial contribution of cytosolic PLA(2)α, not Ca(2+)-independent PLA(2)β, to lipid mobilization in proximal mast cells and distal fibroblasts.Mitochondrial dysfunction and β-cell failure in type 2 diabetes mellitus.Group VIA PLA2 (iPLA2β) is activated upstream of p38 mitogen-activated protein kinase (MAPK) in pancreatic islet β-cell signalingActivation of mitochondrial calcium-independent phospholipase A2γ (iPLA2γ) by divalent cations mediating arachidonate release and production of downstream eicosanoids.Calcium-independent phospholipases A2 and their roles in biological processes and diseases.Smooth muscle-specific expression of calcium-independent phospholipase A2β (iPLA2β) participates in the initiation and early progression of vascular inflammation and neointima formationGenetic ablation of calcium-independent phospholipase A(2)γ (iPLA(2)γ) attenuates calcium-induced opening of the mitochondrial permeability transition pore and resultant cytochrome c release.Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediatorsMechanism-based inhibition of iPLA2β demonstrates a highly reactive cysteine residue (C651) that interacts with the active site: mass spectrometric elucidation of the mechanisms underlying inhibitionCytosolic phospholipase A2α promotes pulmonary inflammation and systemic disease during Streptococcus pneumoniae infection.Interaction between VEGF and calcium-independent phospholipase A2 in proliferation and migration of retinal pigment epithelium.Signal transduction and modulating pathways in tryptamine-evoked vasopressor responses of the rat isolated perfused mesenteric bed.Endothelial cell prostaglandin I(2) and platelet-activating factor production are markedly attenuated in the calcium-independent phospholipase A(2)beta knockout mouseLipoquality control by phospholipase A2 enzymes.The structure of iPLA2β reveals dimeric active sites and suggests mechanisms of regulation and localization.
P2860
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P2860
Smooth muscle cell arachidonic acid release, migration, and proliferation are markedly attenuated in mice null for calcium-independent phospholipase A2beta.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Smooth muscle cell arachidonic ...... ependent phospholipase A2beta.
@en
type
label
Smooth muscle cell arachidonic ...... ependent phospholipase A2beta.
@en
prefLabel
Smooth muscle cell arachidonic ...... ependent phospholipase A2beta.
@en
P2093
P2860
P356
P1476
Smooth muscle cell arachidonic ...... ependent phospholipase A2beta.
@en
P2093
Christopher M Jenkins
David J Mancuso
Richard W Gross
Sung Ho Moon
P2860
P304
33975-33987
P356
10.1074/JBC.M805817200
P407
P577
2008-10-16T00:00:00Z