Tryptase inhibition blocks airway inflammation in a mouse asthma model.
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Active monomers of human beta-tryptase have expanded substrate specificitiesHuman subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutationsTryptase genetics and anaphylaxisThe B12 anti-tryptase monoclonal antibody disrupts the tetrameric structure of heparin-stabilized beta-tryptase to form monomers that are inactive at neutral pH and active at acidic pHPulmonary mastocytosis and enhanced lung inflammation in mice heterozygous null for the Foxf1 geneMouse chromosome 17A3.3 contains 13 genes that encode functional tryptic-like serine proteases with distinct tissue and cell expression patternsOpportunistic pathogen Candida albicans elicits a temporal response in primary human mast cells.Chemogenomic identification of Ref-1/AP-1 as a therapeutic target for asthma.Serine protease inhibitor attenuates ovalbumin induced inflammation in mouse model of allergic airway diseaseMast cell peptidases: chameleons of innate immunity and host defense.A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis.Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing.The Serine Protease Inhibitor, 4-(2-aminoethyl) Benzene Sulfonyl Fluoride Hydrochloride, Reduces Allergic Inflammation in a House Dust Mite Allergic Rhinitis Mouse Model.Mast cell proteases as pharmacological targetsMouse mast cell protease-6 and MHC are involved in the development of experimental asthma.Mast cell tryptases and chymases in inflammation and host defense.Modeling allergic asthma in mice: pitfalls and opportunities.Alpha-tryptase gene variation is associated with levels of circulating IgE and lung function in asthma.Protease phenotype of constitutive connective tissue and of induced mucosal mast cells in mice is regulated by the tissue.Mast cell restricted mouse and human tryptase·heparin complexes hinder thrombin-induced coagulation of plasma and the generation of fibrin by proteolytically destroying fibrinogenBiology of mast cell tryptase. An inflammatory mediator.Approaches for analyzing the roles of mast cells and their proteases in vivo.Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis.A Pulmonary Perspective on GASPIDs: Granule-Associated Serine Peptidases of Immune Defense.Allergic lung inflammation promotes atherosclerosis in apolipoprotein E-deficient mice.Protease-proteoglycan complexes of mouse and human mast cells and importance of their beta-tryptase-heparin complexes in inflammation and innate immunity.Mast cell proteases as protective and inflammatory mediators.Mast cells in asthma--state of the art.Tryptase inhibitors: a patent review.Therapeutic effect of intratracheal administration of murine IL-4 receptor antagonist on asthmatic airway inflammation.A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid p.Mast cells protect mice from Mycoplasma pneumonia.Respiratory syncytial virus infection reversed anti-asthma effect of neonatal Bacillus Calmette-Guerin vaccination in BALB/c mice.Trichostatin A attenuates airway inflammation in mouse asthma model.Toxoplasma gondii serine-protease inhibitor-1: A new adjuvant candidate for asthma therapy.Neutrophil elastase induces mucus cell metaplasia in mouse lung.Neutrophilia, gelatinase release and microvascular leakage induced by human mast cell tryptase in a mouse model: Lack of a role of protease activated receptor 2 (PAR2).Cytotoxic T lymphocyte antigen 4 immunoglobulin modified dendritic cells attenuate allergic airway inflammation and hyperresponsiveness by regulating the development of T helper type 1 (Th1)/Th2 and Th2/regulatory T cell subsets in a murine model ofVitamin A maintains the airway epithelium in a murine model of asthma by suppressing glucocorticoid-induced leucine zipper.Intranasal delivery of the cytoplasmic domain of CTLA-4 using a novel protein transduction domain prevents allergic inflammation.
P2860
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P2860
Tryptase inhibition blocks airway inflammation in a mouse asthma model.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Tryptase inhibition blocks airway inflammation in a mouse asthma model.
@en
type
label
Tryptase inhibition blocks airway inflammation in a mouse asthma model.
@en
prefLabel
Tryptase inhibition blocks airway inflammation in a mouse asthma model.
@en
P2093
P1476
Tryptase inhibition blocks airway inflammation in a mouse asthma model.
@en
P2093
Bolong Cao
Chong I Pae
Cyprian Ogbu
Dong-Keun Lee
Emil Y Chi
Falaah Jones
Geoffrey Kozu
Gertrude K S Chiang
Hiroshi Nakanishi
Hwa-Ok Kim
P304
P356
10.4049/JIMMUNOL.168.4.1992
P407
P577
2002-02-01T00:00:00Z