about
Mechanisms and consequences of bacterial resistance to antimicrobial peptidesStructure of a mutant EF-G reveals domain III and possibly the fusidic acid binding siteInterplay in the selection of fluoroquinolone resistance and bacterial fitnessSelection of resistant bacteria at very low antibiotic concentrationsCo-evolution of the tuf genes links gene conversion with the generation of chromosomal inversions.The processive kinetics of gene conversion in bacteria.Biological cost of single and multiple norfloxacin resistance mutations in Escherichia coli implicated in urinary tract infections.Hyper-susceptibility of a fusidic acid-resistant mutant of Salmonella to different classes of antibiotics.Genetic complexity of fusidic acid-resistant small colony variants (SCV) in Staphylococcus aureus.Persistence of antibiotic resistance in bacterial populations.Fusidic acid-resistant mutants of Salmonella enterica serovar Typhimurium with low fitness in vivo are defective in RpoS induction.Genome-wide detection of spontaneous chromosomal rearrangements in bacteriaReducing ppGpp level rescues an extreme growth defect caused by mutant EF-Tu.Exploiting genomics, genetics and chemistry to combat antibiotic resistance.Acetate availability and utilization supports the growth of mutant sub-populations on aging bacterial coloniesThe Selective Advantage of Synonymous Codon Usage Bias in Salmonella.Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB).Identification of the genetic basis for clinical menadione-auxotrophic small-colony variant isolates of Staphylococcus aureus.Gene amplification and adaptive evolution in bacteria.Antibiotic resistance and its cost: is it possible to reverse resistance?Biological roles of translesion synthesis DNA polymerases in eubacteria.Selection of resistance at lethal and non-lethal antibiotic concentrations.Discovery and preclinical development of new antibiotics.Microbiological effects of sublethal levels of antibiotics.Selection and evolution of resistance to antimicrobial drugs.Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms.Using the power of genetic suppressors to probe the essential functions of RNase E.Weak mutators can drive the evolution of fluoroquinolone resistance in Escherichia coli.Rifampicin Resistance: Fitness Costs and the Significance of Compensatory Evolution.A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants.Mutation Supply and Relative Fitness Shape the Genotypes of Ciprofloxacin-Resistant Escherichia coliEvidence for the critical role of a secondary site rpoB mutation in the compensatory evolution and successful transmission of an MDR tuberculosis outbreak strain.Ciprofloxacin selects for RNA polymerase mutations with pleiotropic antibiotic resistance effects.Temperature-sensitive mutants of RNase E in Salmonella enterica.Autoregulation of the tufB operon in Salmonella.Fusidic acid-resistant mutants of Salmonella enterica serovar typhimurium have low levels of heme and a reduced rate of respiration and are sensitive to oxidative stress.A new mutation in 16S rRNA of Escherichia coli conferring spectinomycin resistance.Discovery and structure-activity relationships of a novel isothiazolone class of bacterial type II topoisomerase inhibitors.Ternary complex-ribosome interaction: its influence on protein synthesis and on growth rate.
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hulumtues
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հետազոտող
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Diarmaid Hughes
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Diarmaid Hughes
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Diarmaid Hughes
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Diarmaid Hughes
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Diarmaid Hughes
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Diarmaid Hughes
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Diarmaid Hughes
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Diarmaid Hughes
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Diarmaid Hughes
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Diarmaid Hughes
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Diarmaid Hughes
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Diarmaid Hughes
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Diarmaid Hughes
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Diarmaid Hughes
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Diarmaid Hughes
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1956-01-20T00:00:00Z
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