Mechanical induction of PGE2 in osteocytes blocks glucocorticoid-induced apoptosis through both the β-catenin and PKA pathways. - Wikidata - awgldk - TriplyDB

Mechanical induction of PGE2 in osteocytes blocks glucocorticoid-induced apoptosis through both the β-catenin and PKA pathways.

Mechanical induction of PGE2 in osteocytes blocks glucocorticoid-induced apoptosis through both the β-catenin and PKA pathways.

http://www.wikidata.org/entity/Q38552512

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The amazing osteocyte In vitro and in vivo approaches to study osteocyte biology Apoptotic osteocytes and the control of targeted bone resorption Connexin 43 hemichannels and intracellular signaling in bone cells Physiological mechanisms and therapeutic potential of bone mechanosensing.Regulation of Wnt/β-catenin signaling within and from osteocytes Load regulates bone formation and Sclerostin expression through a TGFβ-dependent mechanism Biomechanics and mechanobiology of trabecular bone: a review.METTL21C is a potential pleiotropic gene for osteoporosis and sarcopenia acting through the modulation of the NF-κB signaling pathway.Oridonin induces G2/M cell cycle arrest and apoptosis via the PI3K/Akt signaling pathway in hormone-independent prostate cancer cells.Skeletal muscle Ca(2+) mishandling: Another effect of bone-to-muscle signaling.Integrative transcriptomic and proteomic analysis of osteocytic cells exposed to fluid flow reveals novel mechano-sensitive signaling pathways.Activation of β-catenin signaling in MLO-Y4 osteocytic cells versus 2T3 osteoblastic cells by fluid flow shear stress and PGE2: Implications for the study of mechanosensation in bone Deletion of a single β-catenin allele in osteocytes abolishes the bone anabolic response to loading Cyclic compressive loading on 3D tissue of human synovial fibroblasts upregulates prostaglandin E2 via COX-2 production without IL-1β and TNF-α CCL7 is a protective factor secreted by mechanically loaded osteocytes A new method to investigate how mechanical loading of osteocytes controls osteoblasts PTH1-34 blocks radiation-induced osteoblast apoptosis by enhancing DNA repair through canonical Wnt pathway Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger Connexin 43 channels are essential for normal bone structure and osteocyte viability Cx43 and mechanotransduction in bone.Regulation of cellular function by connexin hemichannels.Cell line IDG-SW3 replicates osteoblast-to-late-osteocyte differentiation in vitro and accelerates bone formation in vivo.In vivo mechanical loading rapidly activates β-catenin signaling in osteocytes through a prostaglandin mediated mechanism.Cell autonomous requirement of connexin 43 for osteocyte survival: consequences for endocortical resorption and periosteal bone formation.Puerarin attenuates glucocorticoid-induced apoptosis of hFOB1.19 cells through the JNK- and Akt-mediated mitochondrial apoptotic pathways.Update on Wnt signaling in bone cell biology and bone disease.A specific role for phosphoinositide 3-kinase and AKT in osteoblasts?Bone and skeletal muscle: Key players in mechanotransduction and potential overlapping mechanisms.Mechanical Loading Attenuates Radiation-Induced Bone Loss in Bone Marrow Transplanted Mice Mitogen-activated Protein Kinase (MAPK) Activated by Prostaglandin E2 Phosphorylates Connexin 43 and Closes Osteocytic Hemichannels in Response to Continuous Flow Shear Stress.Skeletal muscle secreted factors prevent glucocorticoid-induced osteocyte apoptosis through activation of β-catenin Beyond gap junctions: Connexin43 and bone cell signaling For whom the bell tolls: distress signals from long-lived osteocytes and the pathogenesis of metabolic bone diseases.Crosstalk between caveolin-1/extracellular signal-regulated kinase (ERK) and β-catenin survival pathways in osteocyte mechanotransduction Isolation and Functional Analysis of an Immortalized Murine Cementocyte Cell Line, IDG-CM6 Connexin 43 channels protect osteocytes against oxidative stress-induced cell death.Constitutive protein kinase A activity in osteocytes and late osteoblasts produces an anabolic effect on bone Simulated Interventions to Ameliorate Age-Related Bone Loss Indicate the Importance of Timing LRP5 and bone mass regulation: Where are we now?

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Mechanical induction of PGE2 in osteocytes blocks glucocorticoid-induced apoptosis through both the β-catenin and PKA pathways.

http://www.wikidata.org/entity/Q38552512

description

2010 nî lūn-bûn

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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2010年论文

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2010年论文

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name

Mechanical induction of PGE2 i ...... he β-catenin and PKA pathways.

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type

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Mechanical induction of PGE2 i ...... he β-catenin and PKA pathways.

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Mechanical induction of PGE2 i ...... he β-catenin and PKA pathways.

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Journal of Bone and Mineral Research

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Mechanical induction of PGE2 i ...... he β-catenin and PKA pathways.

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Hai Qing

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Jean X Jiang

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Leonardo Barragan

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Lynda F Bonewald

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Mark L Johnson

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Shino Kondoh

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P2860

High bone mass in mice expressing a mutant LRP5 gene

The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment

Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta

GSK-3beta regulation in skeletal muscles by adrenaline and insulin: evidence that PKA and PKB regulate different pools of GSK-3

Anti-inflammatory effects of prostaglandin E2 in the central nervous system in response to brain injury and circulating lipopolysaccharide.

In situ measurement of solute transport in the bone lacunar-canalicular system.

Prostaglandin promotion of osteocyte gap junction function through transcriptional regulation of connexin 43 by glycogen synthase kinase 3/beta-catenin signaling.

Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin

Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin

Phosphorylation of glycogen synthase kinase-3 and stimulation of T-cell factor signaling following activation of EP2 and EP4 prostanoid receptors by prostaglandin E2.

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2657-2668

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10.1002/JBMR.168

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12

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25

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44800215

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20578217

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3179278

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