Cathepsin K Inhibition: A New Mechanism for the Treatment of Osteoporosis.
about
Effects of odanacatib on bone matrix mineralization in rhesus monkeys are similar to those of alendronateDiscovery of a New Class of Cathepsin K Inhibitors in Rhizoma Drynariae as Potential Candidates for the Treatment of Osteoporosis.Osteoporosis Therapy: Bone Modeling during Growth and Aging.Long-term treatment with odanacatib maintains normal trabecular biomechanical properties in ovariectomized adult monkeys as demonstrated by micro-CT-based finite element analysis.Computational investigation of conformational variability and allostery in cathepsin K and other related peptidases.Pediatric Osteoporosis: Diagnosis and Treatment Considerations.Pharmacological and biological therapeutic strategies for osteogenesis imperfecta.Calpain research for drug discovery: challenges and potential.Engineered nanomaterial-induced lysosomal membrane permeabilization and anti-cathepsin agents.Applicability of in vitro-in vivo translation of cathepsin K inhibition from animal species to human with the use of free-drug hypothesis.Targeting subchondral bone mesenchymal stem cell activities for intrinsic joint repair in osteoarthritis.Cathepsin K modulates invasion, migration and adhesion of oral squamous cell carcinomas in vitro.Tanshinones that selectively block the collagenase activity of cathepsin K provide a novel class of ectosteric antiresorptive agents for bone.An allosteric site enables fine-tuning of cathepsin K by diverse effectors.Role of Muramyl Dipeptide in Lipopolysaccharide-Mediated Biological Activity and Osteoclast Activity.An Ectosteric Inhibitor of Cathepsin K Inhibits Bone Resorption in Ovariectomized Mice.Advances in the discovery of cathepsin K inhibitors on bone resorption.Cathepsin K inhibition preserves compressive load in lumbar vertebrae of osteoporotic monkeysCysteine proteases in protozoan parasites
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P2860
Cathepsin K Inhibition: A New Mechanism for the Treatment of Osteoporosis.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Cathepsin K Inhibition: A New Mechanism for the Treatment of Osteoporosis.
@en
type
label
Cathepsin K Inhibition: A New Mechanism for the Treatment of Osteoporosis.
@en
prefLabel
Cathepsin K Inhibition: A New Mechanism for the Treatment of Osteoporosis.
@en
P2093
P2860
P1476
Cathepsin K Inhibition: A New Mechanism for the Treatment of Osteoporosis.
@en
P2093
Albert T Leung
Bente Langdahl
Le T Duong
P2860
P2888
P304
P356
10.1007/S00223-015-0051-0
P407
P577
2015-09-03T00:00:00Z
P6179
1014064186