Repeated Administration of Opra Kappa (LY2456302), a Novel, Short-Acting, Selective KOP-r Antagonist, in Persons with and Without Cocaine Dependence.

about

Preclinical evaluation of the kappa-opioid receptor antagonist CERC-501 as a candidate therapeutic for alcohol use disorders.Involvement of activated brain stress responsive systems in excessive and "relapse" alcohol drinking in rodent models: implications for therapeutics.

P2860

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P2860

Repeated Administration of Opra Kappa (LY2456302), a Novel, Short-Acting, Selective KOP-r Antagonist, in Persons with and Without Cocaine Dependence.

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http://www.wikidata.org/entity/Q38600702

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2017 nî lūn-bûn

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2017年の論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年论文

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2017年论文

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2017年论文

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name

Repeated Administration of Opr ...... nd Without Cocaine Dependence.

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type

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Repeated Administration of Opr ...... nd Without Cocaine Dependence.

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Repeated Administration of Opr ...... nd Without Cocaine Dependence.

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P1476

Repeated Administration of Opr ...... nd Without Cocaine Dependence.

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P2093

Brian Reed

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Eduardo R Butelman

http://www.w3.org/2001/XMLSchema#string

Rachel Kimani

http://www.w3.org/2001/XMLSchema#string

Rebecca S Fry

http://www.w3.org/2001/XMLSchema#string

P2860

Duration of action of a broad range of selective κ-opioid receptor antagonists is positively correlated with c-Jun N-terminal kinase-1 activation

κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction

Nalmefene induced elevation in serum prolactin in normal human volunteers: partial kappa opioid agonist activity?

Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats

Psychotomimesis mediated by kappa opiate receptors

Ablation of kappa-opioid receptors from brain dopamine neurons has anxiolytic-like effects and enhances cocaine-induced plasticity

Effects of the plant-derived hallucinogen salvinorin A on basal dopamine levels in the caudate putamen and in a conditioned place aversion assay in mice: agonist actions at kappa opioid receptors.

LY2456302 is a novel, potent, orally-bioavailable small molecule kappa-selective antagonist with activity in animal models predictive of efficacy in mood and addictive disorders.

Safety, tolerability, and pharmacokinetic evaluation of single- and multiple-ascending doses of a novel kappa opioid receptor antagonist LY2456302 and drug interaction with ethanol in healthy subjects.

Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients.

P2888

npp.2017.205

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739-750

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scholarly article

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10.1038/NPP.2017.205

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English

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Mary Jeanne Kreek

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2017-08-31T00:00:00Z

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1091410843

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28857070

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5809790

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Repeated Administration of Opra Kappa (LY2456302), a Novel, Short-Acting, Selective KOP-r Antagonist, in Persons with and Without Cocaine Dependence.

about

P2860

P2860

Repeated Administration of Opra Kappa (LY2456302), a Novel, Short-Acting, Selective KOP-r Antagonist, in Persons with and Without Cocaine Dependence.

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