A mutation in a novel yeast proteasomal gene, RPN11/MPR1, produces a cell cycle arrest, overreplication of nuclear and mitochondrial DNA, and an altered mitochondrial morphology
about
MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 functionSem1p is a novel subunit of the 26 S proteasome from Saccharomyces cerevisiaeUse of RNA interference and complementation to study the function of the Drosophila and human 26S proteasome subunit S13Mdm30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast.Evidence for separable functions of Srp1p, the yeast homolog of importin alpha (Karyopherin alpha): role for Srp1p and Sts1p in protein degradationRole of essential genes in mitochondrial morphogenesis in Saccharomyces cerevisiae.Complementary whole-genome technologies reveal the cellular response to proteasome inhibition by PS-341Nonredundant roles of mitochondria-associated F-box proteins Mfb1 and Mdm30 in maintenance of mitochondrial morphology in yeast.Integrity of the Saccharomyces cerevisiae Rpn11 protein is critical for formation of proteasome storage granules (PSG) and survival in stationary phase.Genetic analysis of TAF68/61 reveals links to cell cycle regulators.Riboflavin uptake and FAD synthesis in Saccharomyces cerevisiae mitochondria: involvement of the Flx1p carrier in FAD export.Rpn6p, a proteasome subunit from Saccharomyces cerevisiae, is essential for the assembly and activity of the 26 S proteasome.Complementary roles for Rpn11 and Ubp6 in deubiquitination and proteolysis by the proteasome.The 19 S proteasomal subunit POH1 contributes to the regulation of c-Jun ubiquitination, stability, and subcellular localizationThe proteasome regulates the UV-induced activation of the AP-1-like transcription factor Gcn4Proteasome assembly influences interaction with ubiquitinated proteins and shuttle factors.Maintenance and integrity of the mitochondrial genome: a plethora of nuclear genes in the budding yeastNovel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme.Proteasome mutants, pre4-2 and ump1-2, suppress the essential function but not the mitochondrial RNase P function of the Saccharomyces cerevisiae gene RPM2.Base-CP proteasome can serve as a platform for stepwise lid formationHomeostasis of redox status derived from glucose metabolic pathway could be the key to understanding the Warburg effect.Proteins that fuse and fragment mitochondria in apoptosis: con-fissing a deadly con-fusion?Dissection of the carboxyl-terminal domain of the proteasomal subunit Rpn11 in maintenance of mitochondrial structure and function.(De)constructing mitochondria: what for?Synthetic lethality of rpn11-1 rpn10Δ is linked to altered proteasome assembly and activityA proteasome assembly defect in rpn3 mutants is associated with Rpn11 instability and increased sensitivity to stress.Regulation of proteolysis by human deubiquitinating enzymes.The Role of the Transmembrane RING Finger Proteins in Cellular and Organelle FunctionMoonlighting and pleiotropy within two regulators of the degradation machinery: the proteasome lid and the CSN.Differential regulation of the catalytic and accessory subunit genes of Drosophila mitochondrial DNA polymerase.Blockade of deubiquitylating enzyme Rpn11 triggers apoptosis in multiple myeloma cells and overcomes bortezomib resistance.Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membrane.Homeostasis of redox status derived from glucose metabolic pathway could be the key to understanding the Warburg effect.Participation of the proteasomal lid subunit Rpn11 in mitochondrial morphology and function is mapped to a distinct C-terminal domain.Functional characterization of the 11 non-ATPase subunit proteins in the trypanosome 19 S proteasomal regulatory complex.Metal-based proteasomal deubiquitinase inhibitors as potential anticancer agents.Analysis of a gene encoding Rpn10 of the fission yeast proteasome reveals that the polyubiquitin-binding site of this subunit is essential when Rpn12/Mts3 activity is compromised.
P2860
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P2860
A mutation in a novel yeast proteasomal gene, RPN11/MPR1, produces a cell cycle arrest, overreplication of nuclear and mitochondrial DNA, and an altered mitochondrial morphology
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
A mutation in a novel yeast pr ...... tered mitochondrial morphology
@en
type
label
A mutation in a novel yeast pr ...... tered mitochondrial morphology
@en
prefLabel
A mutation in a novel yeast pr ...... tered mitochondrial morphology
@en
P2093
P2860
P356
P1476
A mutation in a novel yeast pr ...... tered mitochondrial morphology
@en
P2093
Bolotin-Fukuhara M
Frontali L
P2860
P304
P356
10.1091/MBC.9.10.2917
P577
1998-10-01T00:00:00Z