The novel anticytomegalovirus compound AIC246 (Letermovir) inhibits human cytomegalovirus replication through a specific antiviral mechanism that involves the viral terminase.
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Letermovir and inhibitors of the terminase complex: a promising new class of investigational antiviral drugs against human cytomegalovirusCMV: Prevention, Diagnosis and TherapyClinical utility of viral load in management of cytomegalovirus infection after solid organ transplantationThe DNA helicase-primase complex as a target for herpes viral infectionViral and host control of cytomegalovirus maturationCurrent and potential treatments for ubiquitous but neglected herpesvirus infectionsApproved Antiviral Drugs over the Past 50 YearsHow I treat resistant cytomegalovirus infection in hematopoietic cell transplantation recipientsThe large terminase DNA packaging motor grips DNA with its ATPase domain for cleavage by the flexible nuclease domain.A cutting-edge view on the current state of antiviral drug development.Isolation and characterization of the herpes simplex virus 1 terminase complex.Human cytomegalovirus replication is strictly inhibited by siRNAs targeting UL54, UL97 or UL122/123 gene transcriptsProgress in the development of new therapies for herpesvirus infectionsLimits and patterns of cytomegalovirus genomic diversity in humans.Intermolecular Complementation between Two Varicella-Zoster Virus pORF30 Terminase Domains Essential for DNA Encapsidation.Human cytomegalovirus inhibition by cardiac glycosides: evidence for involvement of the HERG gene.RhoB is a component of the human cytomegalovirus assembly complex and is required for efficient viral production.Replication of CMV in the gut of HIV-infected individuals and epithelial barrier dysfunction.The human cytomegalovirus UL51 protein is essential for viral genome cleavage-packaging and interacts with the terminase subunits pUL56 and pUL89.Adenovirus E1A/E1B Transformed Amniotic Fluid Cells Support Human Cytomegalovirus Replication.A herpes simplex virus scaffold peptide that binds the portal vertex inhibits early steps in viral replication.Cytomegalovirus pneumonia in hematopoietic stem cell recipients.Management of multidrug-resistant viruses in the immunocompromised host.Therapeutic strategies for the prevention and treatment of cytomegalovirus infection.Prevention of cytomegalovirus following solid organ transplantation: a literature review.Design and development of antivirals and intervention strategies against human herpesviruses using high-throughput approach.Anti-herpesvirus agents: a patent and literature review (2003 to present).Cytomegalovirus infection in liver transplant recipients: updates on clinical managementMutual Interplay between the Human Cytomegalovirus Terminase Subunits pUL51, pUL56, and pUL89 Promotes Terminase Complex Formation.Inhibition of Human Cytomegalovirus pUL89 Terminase Subunit Blocks Virus Replication and Genome Cleavage.Human cytomegalovirus antiviral drug resistance in hematopoietic stem cell transplantation: current state of the art.Treatment of CMV infection after allogeneic hematopoietic stem cell transplantation.In vitro drug combination studies of Letermovir (AIC246, MK-8228) with approved anti-human cytomegalovirus (HCMV) and anti-HIV compounds in inhibition of HCMV and HIV replication.A mutation in the DNA polymerase accessory factor of herpes simplex virus 1 restores viral DNA replication in the presence of raltegravir.DSTP-27 prevents entry of human cytomegalovirus.Letermovir for the management of cytomegalovirus infection.Cytomegalovirus infection in lung transplant recipients.Letermovir Treatment of Human Cytomegalovirus Infection Antiinfective Agent.Human herpesvirus vaccines and future directions.In vitro evaluation of the activities of the novel anticytomegalovirus compound AIC246 (letermovir) against herpesviruses and other human pathogenic viruses.
P2860
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P2860
The novel anticytomegalovirus compound AIC246 (Letermovir) inhibits human cytomegalovirus replication through a specific antiviral mechanism that involves the viral terminase.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
The novel anticytomegalovirus ...... involves the viral terminase.
@en
type
label
The novel anticytomegalovirus ...... involves the viral terminase.
@en
prefLabel
The novel anticytomegalovirus ...... involves the viral terminase.
@en
P2093
P2860
P356
P1433
P1476
The novel anticytomegalovirus ...... involves the viral terminase.
@en
P2093
Guy Hewlett
Helga Ruebsamen-Schaeff
Holger Zimmermann
Nicole Ettischer
Peter Lischka
Thomas Goldner
P2860
P304
10884-10893
P356
10.1128/JVI.05265-11
P407
P577
2011-07-13T00:00:00Z