SKAP1 protein PH domain determines RapL membrane localization and Rap1 protein complex formation for T cell receptor (TCR) activation of LFA-1.
about
PI3Kδ promotes CD4(+) T-cell interactions with antigen-presenting cells by increasing LFA-1 binding to ICAM-1.The N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms.Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptorsAnalysis of Phosphorylation-dependent Protein Interactions of Adhesion and Degranulation Promoting Adaptor Protein (ADAP) Reveals Novel Interaction Partners Required for Chemokine-directed T cell Migration.SLAT promotes TCR-mediated, Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1.Screening for protein-protein interactions using Förster resonance energy transfer (FRET) and fluorescence lifetime imaging microscopy (FLIM).Protein kinase A-dependent phosphorylation of Rap1 regulates its membrane localization and cell migrationSLP-76 sterile α motif (SAM) and individual H5 α helix mediate oligomer formation for microclusters and T-cell activation.The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells.D120 and K152 within the PH Domain of T Cell Adapter SKAP55 Regulate Plasma Membrane Targeting of SKAP55 and LFA-1 Affinity Modulation in Human T Lymphocytes.The kindlin 3 pleckstrin homology domain has an essential role in lymphocyte function-associated antigen 1 (LFA-1) integrin-mediated B cell adhesion and migrationIntegrin Activation Through the Hematopoietic Adapter Molecule ADAP Regulates Dendritic Development of Hippocampal Neurons.Tyrosine-phosphorylation of the scaffold protein ADAP and its role in T cell signaling.LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formationAn atlas of mouse CD4(+) T cell transcriptomes.CD8+ Effector T Cell Migration to Pancreatic Islet Grafts Is Dependent on Cognate Antigen Presentation by Donor Graft CellsNon-cleavable talin rescues defect in the T-cell conjugation of T-cells deficient in the immune adaptor SKAP1.Membrane and Protein Interactions of the Pleckstrin Homology Domain Superfamily.T-cell immune adaptor SKAP1 regulates the induction of collagen-induced arthritis in mice.The Role of Mst1 in Lymphocyte Homeostasis and Function.
P2860
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P2860
SKAP1 protein PH domain determines RapL membrane localization and Rap1 protein complex formation for T cell receptor (TCR) activation of LFA-1.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
SKAP1 protein PH domain determ ...... tor (TCR) activation of LFA-1.
@en
type
label
SKAP1 protein PH domain determ ...... tor (TCR) activation of LFA-1.
@en
prefLabel
SKAP1 protein PH domain determ ...... tor (TCR) activation of LFA-1.
@en
P2093
P2860
P356
P1476
SKAP1 protein PH domain determ ...... tor (TCR) activation of LFA-1.
@en
P2093
Christopher E Rudd
Klaus Strebhardt
Monika Raab
Yves Matthess
P2860
P304
29663-29670
P356
10.1074/JBC.M111.222661
P407
P577
2011-06-13T00:00:00Z