Proper activation of MafA is required for optimal differentiation and maturation of pancreatic β-cells

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Exendin-4 enhances the differentiation of Wharton's jelly mesenchymal stem cells into insulin-producing cells through activation of various β-cell markers.

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Proper activation of MafA is required for optimal differentiation and maturation of pancreatic β-cells

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Proper activation of MafA is r ...... turation of pancreatic β-cells

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Proper activation of MafA is r ...... turation of pancreatic β-cells

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Proper activation of MafA is r ...... turation of pancreatic β-cells

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Proper activation of MafA is r ...... turation of pancreatic β-cells

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Arun Sharma

http://www.w3.org/2001/XMLSchema#string

Ilham El Khattabi

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Reprogramming of various cell types to a beta-like state by Pdx1, Ngn3 and MafA

MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene

The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor

MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation

Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA.

Phosphorylation of MafA is essential for its transcriptional and biological properties

MafB is required for islet beta cell maturation

FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site

Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

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scholarly article

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10.1016/J.BEEM.2015.09.006

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P478

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2015-10-09T00:00:00Z

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26696512

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4690007

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Proper activation of MafA is required for optimal differentiation and maturation of pancreatic β-cells

about

P2860

P2860

Proper activation of MafA is required for optimal differentiation and maturation of pancreatic β-cells

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P577

P698

P932