Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II-III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas.
about
Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue DrugsBiosynthesis of Fluorinated Peptaibols Using a Site-Directed Building Block Incorporation Approach.4-Trifluoromethyl-p-quinols as dielectrophiles: three-component, double nucleophilic addition/aromatization reactions.Trifluoromethylation of Arylsilanes with [(phen)CuCF3 ]Biological evaluation of both enantiomers of fluoro-thalidomide using human myeloma cell line H929 and others.Strategic Incorporation of Fluorine into Taxoid Anticancer Agents for Medicinal Chemistry and Chemical Biology Studies.New Coumarin Derivatives as Anti-Breast and Anti-Cervical Cancer Agents Targeting VEGFR-2 and p38α MAPK.The unique fluorine effects in organic reactions: recent facts and insights into fluoroalkylations.The structural modification of natural products for novel drug discovery.USP14 inhibitor attenuates cerebral ischemia/reperfusion-induced neuronal injury in miceFluoroalkyl Amino Reagents (FARs): A General Approach towards the Synthesis of Heterocyclic Compounds Bearing Emergent Fluorinated Substituents.Recent approaches for asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes.A Mechanistic Investigation of the Visible-Light Photocatalytic Trifluoromethylation of Heterocycles Using CF3 I in Flow.Mechanistic studies on intramolecular C-H trifluoromethoxylation of (hetero)arenes via OCF3-migration.Selective C-H trifluoromethylation of benzimidazoles through photoredox catalysis.A practical and catalyst-free trifluoroethylation reaction of amines using trifluoroacetic acid.The Evolution of Pd0/PdII-Catalyzed Aromatic Fluorination.Detrifluoroacetylative Generation of Halogenated Enolates: Practical Access to Perhalogenated Ketones and Alkenes.Chiral phase-transfer catalysis in the asymmetric α-heterofunctionalization of prochiral nucleophilesRhodium-Catalyzed Geminal Oxyfluorination and Oxytrifluoro-Methylation of Diazocarbonyl Compounds.Catalytic asymmetric synthesis of CF3-substituted tertiary propargylic alcohols via direct aldol reaction of α-N3 amideVisible-light-induced oxidant and metal-free dehydrogenative cascade trifluoromethylation and oxidation of 1,6-enynes with waterFluorinative ring-opening of cyclopropanes by hypervalent iodine reagents. An efficient method for 1,3-oxyfluorination and 1,3-difluorination.Tailoring the volatility and stability of oligopeptides.A novel synthetic derivative of quercetin, 8-trifluoromethyl-3,5,7,3',4'-O-pentamethyl-quercetin, inhibits bladder cancer growth by targeting the AMPK/mTOR signaling pathway.Enantioselective Palladium-Catalyzed Oxidative β,β-Fluoroarylation of α,β-Unsaturated Carbonyl Derivatives.Fluorodecarboxylation for the Synthesis of Trifluoromethyl Aryl Ethers.Preparation of imidazo[1,2-a]-N-heterocyclic derivatives with gem-difluorinated side chains.Fluorinated Vinylsilanes from the Copper-Catalyzed Defluorosilylation of Fluoroalkene Feedstocks.A vitamin B12 derivative catalyzed electrochemical trifluoromethylation and perfluoroalkylation of arenes and heteroarenes in organic media.Anionic Derivatives of Perfluorinated Trimethylgold.In situ generation and reactions of p-(trifluoromethyl)benzyl electrophiles: an efficient access to p-(trifluoromethyl)benzyl compounds.Base-catalyzed diastereoselective trimerization of trifluoroacetone.Regioselective decarboxylative addition of malonic acid and its mono(thio)esters to 4-trifluoromethylpyrimidin-2(1H)-ones.Fluorination of some highly functionalized cycloalkanes: chemoselectivity and substrate dependence.Electrophilic trifluoromethylselenolation of terminal alkynes with Se-(trifluoromethyl) 4-methylbenzenesulfonoselenoate.Selective radical trifluoromethylation of native residues in proteins.Protic NNN and NCN Pincer-Type Ruthenium Complexes Featuring (Trifluoromethyl)pyrazole Arms: Synthesis and Application to Catalytic Hydrogen Evolution from Formic Acid.Visible-Light Photocatalytic Decarboxylation of α,β-Unsaturated Carboxylic Acids: Facile Access to Stereoselective Difluoromethylated Styrenes in Batch and Flow.Efficient Encapsulation of Fluorinated Drugs in the Confined Space of Water-Dispersible Fluorous Supraparticles.
P2860
Q28829378-FEE74F35-675E-4379-BC01-D6312671BFF4Q33836344-F2009EAB-EF34-4EF0-BAB7-71AEBDC40F6AQ36953783-1122BC1F-DEF3-4A73-88CE-0109CC5F9457Q37158035-B339A970-FEF1-446F-A11D-605F7CC96923Q38649220-1A028231-A81A-4E4F-A476-7F2DB5509BE2Q38694536-0F5171F9-D8F2-4D2D-8703-F421B900ABF5Q38695524-399D0031-8732-4AD2-BD93-84868C4EEF9BQ38921305-5CBE93AA-1564-4689-A723-B24F3DFD1F50Q39050184-0109B244-BCB4-439E-BF9E-80DCAFF1FBCDQ39059351-D0323AF8-3873-43D0-B270-AC59CAC910A9Q39366624-57DF7702-8131-449D-9E87-6879F16C6E59Q39413035-7338D7CF-6FEC-4E7F-BE36-D1CCE89618B8Q39652144-8BD20462-7735-4DC0-B80B-31A715E578F6Q39864568-3CA89BCE-5DB5-4F02-BD85-D8484E1E06DFQ40432441-859ED851-6059-4D4A-9777-7942F2AB4455Q41007187-FBF5017E-DEC6-4E5F-88CE-E120A67E18FDQ41517598-4197B629-BD62-462F-87B3-3AA007FC1B01Q41574599-EC6DA9AB-41DE-4D29-A96A-FD3F64F00B85Q41594263-3658B32C-94FC-42BD-AE87-1704E96A7956Q41640907-6A9CAE40-03D6-4801-8542-94CA2A57D34AQ41919518-A8960226-F442-4D7C-9194-AC8FED4F11CEQ42285443-EBD0456C-EDA5-4CAB-935A-DA614E199BA3Q42315545-FC4535D6-22A6-4354-A9A8-2FDDD2C553E5Q42359684-4AA6CD79-6874-4B1D-A54F-5532A7C65795Q42700909-28CC018F-F0FB-4C56-B1BE-DC856D8DD8FBQ43644034-0705B3AB-428A-473E-B783-0BC7B3813B4BQ43790264-18D39520-D54B-4EAD-8990-78F3DB79F280Q45851846-9E5FB5BF-11DD-4D07-AD7C-517A30AE7FC3Q46262802-09B1C9C6-B1E3-4AAA-8F4F-F1F1611EA412Q46304137-960A307E-C4C9-4880-B0E5-66D56979B18CQ46401857-092F3D8E-8D3B-49CE-94B1-4B65867A9283Q46430865-6BF976FF-F18C-4411-B4E0-5DCC399B5E74Q46761871-CA4B56F8-DFEB-4063-ABB8-B1564394D912Q47148854-DA59D5B0-38E9-486E-965B-B35475A7AD84Q47150410-2DD5463D-3253-4741-87A3-39413D83B98BQ47159828-C91C6CF9-59ED-4934-B96A-F865AE1F0416Q47232071-FDC26878-B9F5-4BBA-AC86-8960E272FE80Q47345746-13F98094-B47E-4B8D-ADDF-B72852E46DB2Q47375033-3FC8E76B-6939-4909-9D77-9DFCF35281CCQ47378475-6E67A5F8-2E9F-42D3-A542-0BDC8E225B14
P2860
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II-III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年学术文章
@wuu
2016年学术文章
@zh-cn
2016年学术文章
@zh-hans
2016年学术文章
@zh-my
2016年学术文章
@zh-sg
2016年學術文章
@yue
2016年學術文章
@zh
2016年學術文章
@zh-hant
name
Next Generation of Fluorine-Co ...... Trends and Therapeutic Areas.
@en
type
label
Next Generation of Fluorine-Co ...... Trends and Therapeutic Areas.
@en
prefLabel
Next Generation of Fluorine-Co ...... Trends and Therapeutic Areas.
@en
P2093
P1433
P1476
Next Generation of Fluorine-Co ...... l Trends and Therapeutic Areas
@en
P2093
Jiang Wang
Kunisuke Izawa
Shuni Wang
Vadim A Soloshonok
P304
P356
10.1021/ACS.CHEMREV.5B00392
P577
2016-01-12T00:00:00Z