Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions.

Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions.

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http://www.wikidata.org/entity/Q38696200
CRISPR Transcriptional Activation Analysis Unmasks an Occult γ-Secretase Processivity Defect in Familial Alzheimer's Disease Skin Fibroblasts.Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease.Both positional and chemical variables control in vitro proteolytic cleavage of a presenilin ortholog.Taking a position on intramembrane proteolysis.Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation.Transcriptional mutagenesis mediated by 8-oxoG induces translational errors in mammalian cells.Microglia in Alzheimer's diseaseIncreased Insoluble Amyloid-β Induces Negligible Cognitive Deficits in Old AppNL/NL Knock-In MiceBACE1 gene silencing alleviates isoflurane anesthesia‑induced postoperative cognitive dysfunction in immature rats by activating the PI3K/Akt signaling pathway
P2860

Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions.

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http://www.wikidata.org/entity/Q38696200
description
2017 nî lūn-bûn
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2017年の論文
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2017年学术文章
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2017年学术文章
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2017年学术文章
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2017年学术文章
@zh-my
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2017年學術文章
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2017年學術文章
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name
Alzheimer's-Causing Mutations ...... γ-Secretase-Aβn Interactions.
@en
type
label
Alzheimer's-Causing Mutations ...... γ-Secretase-Aβn Interactions.
@en
prefLabel
Alzheimer's-Causing Mutations ...... γ-Secretase-Aβn Interactions.
@en
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P356
P1433
P1476
Alzheimer's-Causing Mutations ...... γ-Secretase-Aβn Interactions.
@en
P2093
P304
P31
P356
10.1016/J.CELL.2017.07.004
P407
P433
P478
P50
P577
P698
P921