Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70
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Insights into the molecular mechanism of allostery in Hsp70s.Structural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocketSelective targeting of the stress chaperome as a therapeutic strategyCombined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcomaIsoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone ComplementThe Chemical Biology of Molecular Chaperones--Implications for Modulation of ProteostasisInhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules.Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines as reversible binders to an allosteric site on heat shock protein 70.The epichaperome is an integrated chaperome network that facilitates tumour survivalTargeting Allosteric Control Mechanisms in Heat Shock Protein 70 (Hsp70).Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer.Affinity purification probes of potential use to investigate the endogenous Hsp70 interactome in cancer.The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics.Morita-Baylis-Hillman reaction of acrylamide with isatin derivatives.Peptide fragments of Hsp70 modulate its chaperone activity and sensitize tumor cells to anti-cancer drugs.High Throughput Screen for Inhibitors of Protein-Protein Interactions in a Reconstituted Heat Shock Protein 70 (Hsp70) Complex.
P2860
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P2860
Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70
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Heat shock protein 70 inhibito ...... site on heat shock protein 70
@en
type
label
Heat shock protein 70 inhibito ...... site on heat shock protein 70
@en
prefLabel
Heat shock protein 70 inhibito ...... site on heat shock protein 70
@en
P2093
P2860
P356
P1476
Heat shock protein 70 inhibito ...... site on heat shock protein 70
@en
P2093
Alexander Gozman
Anna Rodina
Cristina C Clement
Hardik J Patel
Jason C Young
Jeffrey L Brodsky
Maulik R Patel
Pallav D Patel
Ronnie Maharaj
Tony Taldone
P2860
P304
P356
10.1021/JM401551N
P407
P577
2014-02-18T00:00:00Z