Amino Acid Mutations in the NS4A Region of Hepatitis C Virus Contribute to Viral Replication and Infectious Virus Production

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Cell culture-adaptive mutations in hepatitis C virus promote viral production by enhancing viral replication and release.

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Q54245494-7A7B1A07-8FB4-4B52-AECF-5DE387ECD1CA

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Amino Acid Mutations in the NS4A Region of Hepatitis C Virus Contribute to Viral Replication and Infectious Virus Production

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2016 nî lūn-bûn

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2016年の論文

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2016年論文

@yue

2016年論文

@zh-hant

2016年論文

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2016年論文

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2016年論文

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2016年论文

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Amino Acid Mutations in the NS ...... nd Infectious Virus Production

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Amino Acid Mutations in the NS ...... nd Infectious Virus Production

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Amino Acid Mutations in the NS ...... nd Infectious Virus Production

@en

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Amino Acid Mutations in the NS ...... nd Infectious Virus Production

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Asako Murayama

http://www.w3.org/2001/XMLSchema#string

Hidenori Mochizuki

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Masaki Moriyama

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Nao Sugiyama

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Noriko Nakamura

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Ryosuke Suzuki

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Takaji Wakita

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Takanobu Kato

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Signal peptidase complex subunit 1 participates in the assembly of hepatitis C virus through an interaction with E2 and NS2

Subcellular localization, stability, and trans-cleavage competence of the hepatitis C virus NS3-NS4A complex expressed in tetracycline-regulated cell lines.

Robust hepatitis C virus infection in vitro.

Mutations that permit efficient replication of hepatitis C virus RNA in Huh-7 cells prevent productive replication in chimpanzees.

Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing

A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro

The NS3 Helicase and NS5B-to-3'X Regions Are Important for Efficient Hepatitis C Virus Strain JFH-1 Replication in Huh7 Cells

The C Terminus of Hepatitis C Virus NS4A Encodes an Electrostatic Switch That Regulates NS5A Hyperphosphorylation and Viral Replication

Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee

Hepatitis C virus JFH-1 strain infection in chimpanzees is associated with low pathogenicity and emergence of an adaptive mutation

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scholarly article

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10.1128/JVI.02124-16

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English

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2016-12-07T00:00:00Z

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27928005

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5286874

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Amino Acid Mutations in the NS4A Region of Hepatitis C Virus Contribute to Viral Replication and Infectious Virus Production

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P2860

Amino Acid Mutations in the NS4A Region of Hepatitis C Virus Contribute to Viral Replication and Infectious Virus Production

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P1433

P1476

P2093

P2860

P31

P356

P407

P433

P478

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P31

P356

P407

P433

P478

P577

P698

P932