The Dok-3/Grb2 adaptor module promotes inducible association of the lipid phosphatase SHIP with the BCR in a coreceptor-independent manner.

about

Regulation of immune cell signaling by SHIP1: A phosphatase, scaffold protein, and potential therapeutic target.SHIP negatively regulates type II immune responses in mast cells and macrophages.What goes up must come down: A tripartite Dok-3/Grb2/SHIP1 inhibitory module limits BCR signaling.

P2860

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P2860

The Dok-3/Grb2 adaptor module promotes inducible association of the lipid phosphatase SHIP with the BCR in a coreceptor-independent manner.

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http://www.wikidata.org/entity/Q38733606

description

2016 nî lūn-bûn

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2016年の論文

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2016年論文

@yue

2016年論文

@zh-hant

2016年論文

@zh-hk

2016年論文

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2016年論文

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2016年论文

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2016年论文

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2016年论文

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name

The Dok-3/Grb2 adaptor module ...... coreceptor-independent manner.

@en

type

Item

label

The Dok-3/Grb2 adaptor module ...... coreceptor-independent manner.

@en

prefLabel

The Dok-3/Grb2 adaptor module ...... coreceptor-independent manner.

@en

P1476

The Dok-3/Grb2 adaptor module ...... coreceptor-independent manner.

@en

P2093

Birgit Manno

http://www.w3.org/2001/XMLSchema#string

Facundo D Batista

http://www.w3.org/2001/XMLSchema#string

Henning Urlaub

http://www.w3.org/2001/XMLSchema#string

Jasmin Corso

http://www.w3.org/2001/XMLSchema#string

Jürgen Wienands

http://www.w3.org/2001/XMLSchema#string

Konstantin Neumann

http://www.w3.org/2001/XMLSchema#string

Marion Lösing

http://www.w3.org/2001/XMLSchema#string

Michael Engelke

http://www.w3.org/2001/XMLSchema#string

Thomas Oellerich

http://www.w3.org/2001/XMLSchema#string

Tim Schnyder

http://www.w3.org/2001/XMLSchema#string

P2860

Subcellular localization of Grb2 by the adaptor protein Dok-3 restricts the intensity of Ca2+ signaling in B cells

The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85

Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase

Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha

SLP-65 phosphorylation dynamics reveals a functional basis for signal integration by receptor-proximal adaptor proteins

Tyrosine-phosphorylated forms of Ig beta, CD22, TCR zeta and HOSS are major ligands for tandem SH2 domains of Syk

The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters

CIN85 interacting proteins in B cells-specific role for SHIP-1.

Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap.

P304

2520-2530

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P31

scholarly article

P356

10.1002/EJI.201646431

http://www.w3.org/2001/XMLSchema#string

P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P577

2016-08-23T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

27550373

http://www.w3.org/2001/XMLSchema#string

The Dok-3/Grb2 adaptor module promotes inducible association of the lipid phosphatase SHIP with the BCR in a coreceptor-independent manner.

about

P2860

P2860

The Dok-3/Grb2 adaptor module promotes inducible association of the lipid phosphatase SHIP with the BCR in a coreceptor-independent manner.

description

name

type

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P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P577

P698

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P577

P698