Biological significance of PinX1 telomerase inhibitor in esophageal carcinoma treatment.

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Biological significance of PinX1 telomerase inhibitor in esophageal carcinoma treatment.

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2016 nî lūn-bûn

@nan

2016年の論文

@ja

2016年論文

@yue

2016年論文

@zh-hant

2016年論文

@zh-hk

2016年論文

@zh-mo

2016年論文

@zh-tw

2016年论文

@wuu

2016年论文

@zh

2016年论文

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name

Biological significance of PinX1 telomerase inhibitor in esophageal carcinoma treatment.

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label

Biological significance of PinX1 telomerase inhibitor in esophageal carcinoma treatment.

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prefLabel

Biological significance of PinX1 telomerase inhibitor in esophageal carcinoma treatment.

@en

P1476

Biological significance of PinX1 telomerase inhibitor in esophageal carcinoma treatment.

@en

P2093

Jian-Zhe Li

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Jing-Shan Li

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Rui-Hua Yan

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Xiang-Kui Fan

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Xiang-Ming Chen

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Xiang-Qun Geng

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P2860

Identification of the gene for a novel liver-related putative tumor suppressor at a high-frequency loss of heterozygosity region of chromosome 8p23 in human hepatocellular carcinoma

Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR

PinX1 is recruited to the mitotic chromosome periphery by Nucleolin and facilitates chromosome congression

Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA

The yeast homolog of human PinX1 is involved in rRNA and small nucleolar RNA maturation, not in telomere elongation inhibition.

Over-expression of LPTS-L in hepatocellular carcinoma cell line SMMC-7721 induces crisis.

PinX1 is a novel microtubule-binding protein essential for accurate chromosome segregation.

Antisense oligonucleotide-mediated inhibition of hTERT, but not hTERC, induces rapid cell growth decline and apoptosis in the absence of telomere shortening in human prostate cancer cells.

Antisense-mediated hTERT inhibition specifically reduces the growth of human bladder cancer cells.

C-terminal amino acids 290-328 of LPTS/PinX1 confer telomerase inhibition.

P304

2196-2200

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P31

scholarly article

P356

10.3892/ETM.2016.3561

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P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P577

2016-08-01T00:00:00Z

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P698

27698711

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P932

5038363

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