PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2. - Wikidata - awgldk - TriplyDB

PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2.

PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2.

http://www.wikidata.org/entity/Q38744013

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Function, regulation and pathological roles of the Gab/DOS docking proteins A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation Osteoimmunology: interactions of the bone and immune system GAB2--a scaffolding protein in cancer Regulation of osteoclasts by membrane-derived lipid mediators Regulation of NFATc1 in Osteoclast Differentiation Phospholipases of mineralization competent cells and matrix vesicles: roles in physiological and pathological mineralizations Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone mass Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis Signal adaptor DAP10 associates with MDL-1 and triggers osteoclastogenesis in cooperation with DAP12 Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis SH3BP2 cherubism mutation potentiates TNF-α-induced osteoclastogenesis via NFATc1 and TNF-α-mediated inflammatory bone loss.3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions 3BP2 adapter protein is required for receptor activator of NFκB ligand (RANKL)-induced osteoclast differentiation of RAW264.7 cells.Type I phosphotidylinosotol 4-phosphate 5-kinase γ regulates osteoclasts in a bifunctional manner Lymphocytes and the Dap12 adaptor are key regulators of osteoclast activation associated with gonadal failure.Phospholipase C gamma 2 is critical for development of a murine model of inflammatory arthritis by affecting actin dynamics in dendritic cells.Sitagliptin, An Anti-diabetic Drug, Suppresses Estrogen Deficiency-Induced OsteoporosisIn Vivo and Inhibits RANKL-Induced Osteoclast Formation and Bone Resorption In Vitro.Osteoclast motility: putting the brakes on bone resorption.Genetic network identifies novel pathways contributing to atherosclerosis susceptibility in the innominate artery Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis GPCR kinase 2 interacting protein 1 (GIT1) regulates osteoclast function and bone mass MIP-1δ activates NFATc1 and enhances osteoclastogenesis: involvement of both PLCγ2 and NFκB signaling.Vav/Phospholipase Cgamma2-mediated control of a neutrophil-dependent murine model of rheumatoid arthritis.TNF activates calcium-nuclear factor of activated T cells (NFAT)c1 signaling pathways in human macrophages.CD8+ T cells regulate bone tumor burden independent of osteoclast resorption.OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis Impaired Fracture Healing Caused by Deficiency of the Immunoreceptor Adaptor Protein DAP12.Phospholipase Cγ2 is required for basal but not oestrogen deficiency-induced bone resorption.Stauntonia hexaphylla (Lardizabalaceae) leaf methanol extract inhibits osteoclastogenesis and bone resorption activity via proteasome-mediated degradation of c-Fos protein and suppression of NFATc1 expression.Decreased osteoclastogenesis in serotonin-deficient mice.RGS10-null mutation impairs osteoclast differentiation resulting from the loss of [Ca2+]i oscillation regulation Phospholipase Cγ2 Is Required for Luminal Expansion of the Epididymal Duct during Postnatal Development in Mice.The role of SH3BP2 in the pathophysiology of cherubism.Diacylglycerol Kinase ζ (DGKζ) Is a Critical Regulator of Bone Homeostasis Via Modulation of c-Fos Levels in Osteoclasts.Interleukin-33 stimulates formation of functional osteoclasts from human CD14(+) monocytes.TLT-1s, alternative transcripts of triggering receptor expressed on myeloid cell-like transcript-1 (TLT-1), Inhibits the triggering receptor expressed on myeloid cell-2 (TREM-2)-mediated signaling pathway during osteoclastogenesis Transcription Factor CTIP2 Maintains Hair Follicle Stem Cell Pool and Contributes to Altered Expression of LHX2 and NFATC1 Antiresorptive activity of bacillus-fermented antler extracts: inhibition of osteoclast differentiation

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P2860

PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2.

http://www.wikidata.org/entity/Q38744013

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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2006年论文

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2006年论文

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name

PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2.

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type

label

PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2.

@en

prefLabel

PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2.

@en

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Journal of Clinical Investigation

P1476

PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2.

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P2093

Brian Uthgenannt

http://www.w3.org/2001/XMLSchema#string

Dailing Mao

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Deborah V Novack

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Holly Epple

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Roberta Faccio

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P2860

The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis

Evidence for a role for tyrosine phosphorylation of phospholipase C gamma 2 in collagen-induced platelet cytosolic calcium mobilization

Mechanisms of bone loss in inflammatory arthritis: diagnosis and therapeutic implications.

Bone versus immune system

Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice

Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system

Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function

The adapter molecule Gab2 regulates Fc epsilon RI-mediated signal transduction in mast cells

Structure, function, and control of phosphoinositide-specific phospholipase C

NF-kappaB in cancer: from innocent bystander to major culprit

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2869-2879

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10.1172/JCI28775

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11

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116

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2006-10-19T00:00:00Z

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17053833

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1616195

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