The major determinant of attenuation in mice of the Candid1 vaccine for Argentine hemorrhagic fever is located in the G2 glycoprotein transmembrane domain.
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Animal Models for the Study of Rodent-Borne Hemorrhagic Fever Viruses: Arenaviruses and HantavirusesAdvanced vaccine candidates for Lassa feverJunín virus pathogenesis and virus replicationThe Ectodomain of Glycoprotein from the Candid#1 Vaccine Strain of Junin Virus Rendered Machupo Virus Partially Attenuated in Mice Lacking IFN-αβ/γ ReceptorSevere hemorrhagic fever in strain 13/N guinea pigs infected with Lujo virusBiochemical reconstitution of hemorrhagic-fever arenavirus envelope glycoprotein-mediated membrane fusionPotent inhibition of Junín virus infection by interferon in murine cells.RIG-I enhanced interferon independent apoptosis upon Junin virus infection.An attenuated Machupo virus with a disrupted L-segment intergenic region protects guinea pigs against lethal Guanarito virus infection.Comparative analysis of disease pathogenesis and molecular mechanisms of New World and Old World arenavirus infections.Evolution of recombinant lymphocytic choriomeningitis virus/Lassa virus in vivo highlights the importance of the GPC cytosolic tail in viral fitness.Drug discovery technologies and strategies for Machupo virus and other New World arenaviruses.The curious case of arenavirus entry, and its inhibition.Vaccination strategies against highly pathogenic arenaviruses: the next steps toward clinical trialsJunin virus infects mouse cells and induces innate immune responses.Development of live-attenuated arenavirus vaccines based on codon deoptimizationThe glycoprotein precursor gene of Junin virus determines the virulence of the Romero strain and the attenuation of the Candid #1 strain in a representative animal model of Argentine hemorrhagic fever.Novel Arenavirus Entry Inhibitors Discovered by Using a Minigenome Rescue System for High-Throughput Drug Screening.Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection.Reverse genetics recovery of Lujo virus and role of virus RNA secondary structures in efficient virus growth.Machupo Virus Expressing GPC of the Candid#1 Vaccine Strain of Junin Virus Is Highly Attenuated and Immunogenic.Vaccines for viral hemorrhagic fevers--progress and shortcomingsMyristoylation of the Arenavirus Envelope Glycoprotein Stable Signal Peptide Is Critical for Membrane Fusion but Dispensable for Virion MorphogenesisGeneration of recombinant arenavirus for vaccine development in FDA-approved Vero cells.Watching every step of the way: junín virus attenuation markers in the vaccine lineage.Development of live-attenuated arenavirus vaccines based on codon deoptimization of the viral glycoprotein.Targeting virulence mechanisms for the prevention and therapy of arenaviral hemorrhagic fever.Human hemorrhagic Fever causing arenaviruses: molecular mechanisms contributing to virus virulence and disease pathogenesis.Absence of an N-Linked Glycosylation Motif in the Glycoprotein of the Live-Attenuated Argentine Hemorrhagic Fever Vaccine, Candid #1, Results in Its Improper Processing, and Reduced Surface Expression.Structure-function relationship of the mammarenavirus envelope glycoprotein.General Molecular Strategy for Development of Arenavirus Live-Attenuated Vaccines.Substitutions in the glycoprotein (GP) of the Candid#1 vaccine strain of Junin virus increase dependence on human transferrin receptor 1 for entry and destabilize the metastable conformation of GPArenavirus Genome Rearrangement for the Development of Live Attenuated Vaccines.A substitution in the transmembrane region of the glycoprotein leads to an unstable attenuation of Machupo virus.Differences in Glycoprotein Complex Receptor Binding Site Accessibility Prompt Poor Cross-Reactivity of Neutralizing Antibodies between Closely Related Arenaviruses.Epistastic interactions within the Junín virus envelope glycoprotein complex provide an evolutionary barrier to reversion in the live-attenuated Candid#1 vaccine.A vaccine platform against arenaviruses based on a recombinant hyper-attenuated Mopeia virus expressing heterologous glycoproteins.Neutralization of Junín virus by single domain antibodies targeted against the nucleoprotein
P2860
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P2860
The major determinant of attenuation in mice of the Candid1 vaccine for Argentine hemorrhagic fever is located in the G2 glycoprotein transmembrane domain.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
The major determinant of atten ...... oprotein transmembrane domain.
@en
type
label
The major determinant of atten ...... oprotein transmembrane domain.
@en
prefLabel
The major determinant of atten ...... oprotein transmembrane domain.
@en
P2093
P2860
P356
P1433
P1476
The major determinant of atten ...... oprotein transmembrane domain.
@en
P2093
Ayan K Chakrabarti
Brian H Bird
César G Albariño
David M White
Eric Bergeron
Kimberly A Dodd
Mike Flint
P2860
P304
10404-10408
P356
10.1128/JVI.00856-11
P407
P577
2011-07-27T00:00:00Z