Wee1 Kinase Inhibitor AZD1775 Radiosensitizes Hepatocellular Carcinoma Regardless of TP53 Mutational Status Through Induction of Replication Stress.

Wee1 Kinase Inhibitor AZD1775 Radiosensitizes Hepatocellular Carcinoma Regardless of TP53 Mutational Status Through Induction of Replication Stress.

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http://www.wikidata.org/entity/Q38786439
AZD1775 Induces Toxicity Through Double-Stranded DNA Breaks Independently of Chemotherapeutic Agents in p53-Mutated Colorectal Cancer Cells.Mutational status of TP53 defines the efficacy of Wee1 inhibitor AZD1775 in KRAS-mutant non-small cell lung cancer.PARP1 Trapping and DNA Replication Stress Enhance Radiosensitization with Combined WEE1 and PARP Inhibitors.ATP-binding cassette transporters limit the brain penetration of Wee1 inhibitors.New therapeutic strategies to treat human cancers expressing mutant p53 proteins.Inactivation of DNA-PK by knockdown DNA-PKcs or NU7441 impairs non-homologous end-joining of radiation-induced double strand break repair.Inhibition of WEE1 kinase and cell cycle checkpoint activation sensitizes head and neck cancers to natural killer cell therapies.WEE1 kinase inhibition reverses G2/M cell cycle checkpoint activation to sensitize cancer cells to immunotherapy
P2860

Wee1 Kinase Inhibitor AZD1775 Radiosensitizes Hepatocellular Carcinoma Regardless of TP53 Mutational Status Through Induction of Replication Stress.

Item
http://www.wikidata.org/entity/Q38786439
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Wee1 Kinase Inhibitor AZD1775 ...... duction of Replication Stress.
@en
type
label
Wee1 Kinase Inhibitor AZD1775 ...... duction of Replication Stress.
@en
prefLabel
Wee1 Kinase Inhibitor AZD1775 ...... duction of Replication Stress.
@en
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P577
P698
P932
P356
P1433
P1476
Wee1 Kinase Inhibitor AZD1775 ...... duction of Replication Stress.
@en
P2093
P304
P31
P356
10.1016/J.IJROBP.2016.01.028
P407
P433
P478
P577
P698
P932