about
Herpes simplex virus interferes with amyloid precursor protein processingCellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein.Membrane raft actin deficiency and altered Ca2+-induced vesiculation in stomatin-deficient overhydrated hereditary stomatocytosis.ADAMs family members as amyloid precursor protein alpha-secretases.Stroma-induced Jagged1 expression drives PC3 prostate cancer cell migration; disparate effects of RIP-generated proteolytic fragments on cell behaviour and Notch signaling.The E1 copper binding domain of full-length amyloid precursor protein mitigates copper-induced growth inhibition in brain metastatic prostate cancer DU145 cells.The histidine composition of the amyloid-β domain, but not the E1 copper binding domain, modulates β-secretase processing of amyloid-β protein precursor in Alzheimer's disease.The amyloid precursor protein represses expression of acetylcholinesterase in neuronal cell linesCopper modulates zinc metalloproteinase-dependent ectodomain shedding of key signaling and adhesion proteins and promotes the invasion of prostate cancer epithelial cells.Development of a proteolytically stable retro-inverso peptide inhibitor of beta-amyloid oligomerization as a potential novel treatment for Alzheimer's disease.Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein.Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein.A disintegrin and metalloproteinase (ADAM)-mediated ectodomain shedding of ADAM10.Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2).The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein.Dual mechanisms for shedding of the cellular prion protein.Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha.A point mutation in the juxtamembrane stalk of human angiotensin I-converting enzyme invokes the action of a distinct secretase.The amyloid precursor protein is not enriched in caveolae-like, detergent-insoluble membrane microdomains.Zinc metalloproteinases and amyloid Beta-Peptide metabolism: the positive side of proteolysis in Alzheimer's disease.Isolation and characterization of two distinct low-density, Triton-insoluble, complexes from porcine lung membranes.The ectodomain shedding of angiotensin-converting enzyme is independent of its localisation in lipid rafts.Ectodomain shedding of the Notch ligand Jagged1 is mediated by ADAM17, but is not a lipid-raft-associated event.Angiotensin-converting enzyme as a GPIase: a critical reevaluation.Characterization of detergent-insoluble complexes containing the familial Alzheimer's disease-associated presenilins.A role for calcium and annexins in the formation of caveolae.Osteonectin as a screening marker for pancreatic cancer: A prospective studyModulation of phosphatidylcholine biosynthesis in celery by exogenous fatty acids
P50
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P50
description
hulumtues
@sq
researcher
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wetenschapper
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հետազոտող
@hy
name
Edward Parkin
@ast
Edward Parkin
@en
Edward Parkin
@es
Edward Parkin
@nl
Edward Parkin
@sl
type
label
Edward Parkin
@ast
Edward Parkin
@en
Edward Parkin
@es
Edward Parkin
@nl
Edward Parkin
@sl
prefLabel
Edward Parkin
@ast
Edward Parkin
@en
Edward Parkin
@es
Edward Parkin
@nl
Edward Parkin
@sl
P106
P21
P31
P496
0000-0003-3270-3184