about
Rab27a and Rab27b control different steps of the exosome secretion pathwayDefective cellular trafficking of missense NPR-B mutants is the major mechanism underlying acromesomelic dysplasia-type MaroteauxThe leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytesA novel statin-mediated "prenylation block-and-release" assay provides insight into the membrane targeting mechanisms of small GTPases.Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland.Rab27a-mediated protease release regulates neutrophil recruitment by allowing uropod detachmentMyosin Va's adaptor protein melanophilin enforces track selection on the microtubule and actin networks in vitro.A role for Na+,K+-ATPase α1 in regulating Rab27a localisation on melanosomes.Rab GTPases, intracellular traffic and disease.Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases.Prenylation of Rab GTPases: molecular mechanisms and involvement in genetic disease.A role for Rab27 in neutrophil chemotaxis and lung recruitment.Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria.Melanosomes at a glance.Membrane targeting of Rab GTPases is influenced by the prenylation motifSemi-automated analysis of organelle movement and membrane content: understanding rab-motor complex transport functionRab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells.Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranesMelanosomes on the move: a model to understand organelle dynamics.Rab27a and melanosomes: a model to investigate the membrane targeting of Rabs.Inefficient recruitment of kinesin-1 to melanosomes precludes it from facilitating their transportA coiled-coil domain of melanophilin is essential for Myosin Va recruitment and melanosome transport in melanocytes.Myrip uses distinct domains in the cellular activation of myosin VA and myosin VIIA in melanosome transport.Myosin--a monarch of pigment transport?Correction: A Role for Na+,K+-ATPase α1 in Regulating Rab27a Localisation on Melanosomes.Myosin-Va and dynamic actin oppose microtubules to drive long-range organelle transport.Rab11b mediates melanin transfer between donor melanocytes and acceptor keratinocytes via coupled exo/endocytosis.Retention in the endoplasmic reticulum is the underlying mechanism of some hereditary haemorrhagic telangiectasia type 2 ALK1 missense mutations.Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretionNucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a.Weibel-Palade bodies recruit Rab27 by a content-driven, maturation-dependent mechanism that is independent of cell typeRab27a and MyoVa are the primary Mlph interactors regulating melanosome transport in melanocytesMelanoma goes on a diet to get moving: toning down phagocytic Rab7 expression helps melanoma to metastasise
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Alistair N Hume
@ast
Alistair N Hume
@en
Alistair N Hume
@es
Alistair N Hume
@nl
type
label
Alistair N Hume
@ast
Alistair N Hume
@en
Alistair N Hume
@es
Alistair N Hume
@nl
prefLabel
Alistair N Hume
@ast
Alistair N Hume
@en
Alistair N Hume
@es
Alistair N Hume
@nl
P106
P21
P31
P496
0000-0001-9443-1087