Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents.
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Taking a Bad Turn: Compromised DNA Damage Response in LeukemiaOncometabolites d- and l-2-Hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological ConditionsRhein Inhibits AlkB Repair Enzymes and Sensitizes Cells to Methylated DNA DamagePLK1 inhibition enhances temozolomide efficacy in IDH1 mutant gliomas.Roles of IDH1/2 and TET2 mutations in myeloid disorders.L2hgdh Deficiency Accumulates l-2-Hydroxyglutarate with Progressive Leukoencephalopathy and Neurodegeneration.Regulation of DNA Alkylation Damage Repair: Lessons and Therapeutic Opportunities.Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling.Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL.A clinical perspective on the 2016 WHO brain tumor classification and routine molecular diagnostics.Glutamine deficiency induces DNA alkylation damage and sensitizes cancer cells to alkylating agents through inhibition of ALKBH enzymes.Wild-type and mutated IDH1/2 enzymes and therapy responses.The DNA methylome of DDR genes and benefit from RT or TMZ in IDH mutant low-grade glioma treated in EORTC 22033.Metabolism, Activity, and Targeting of D- and L-2-Hydroxyglutarates.Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas.The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe Hypoxia.Evolving Treatment Strategies for Elderly Leukemia Patients with IDH Mutations.
P2860
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P2860
Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Oncometabolite D-2-Hydroxyglut ...... nt Cells to Alkylating Agents.
@en
type
label
Oncometabolite D-2-Hydroxyglut ...... nt Cells to Alkylating Agents.
@en
prefLabel
Oncometabolite D-2-Hydroxyglut ...... nt Cells to Alkylating Agents.
@en
P2093
P2860
P1433
P1476
Oncometabolite D-2-Hydroxyglut ...... ant Cells to Alkylating Agents
@en
P2093
Kun-Liang Guan
Matthew D Wilkerson
Shenghong Ma
P2860
P304
P356
10.1016/J.CELREP.2015.11.029
P577
2015-12-10T00:00:00Z