Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.
about
Lysosomal processing of progranulinThe lysosomal protein cathepsin L is a progranulin protease.Progranulin acts as a shared chaperone and regulates multiple lysosomal enzymes.Another piece in the progranulin puzzle: special binding between progranulin and prosaposin creates additional lysosomal access: An Editorial Comment for 'The interaction between progranulin and prosaposin is mediated by granulins and the linker regProgranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis.The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C.Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients.The lysosomal function of progranulin, a guardian against neurodegenerationEarly lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice
P2860
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P2860
Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.
description
2017 nî lūn-bûn
@nan
2017年の論文
@ja
2017年論文
@yue
2017年論文
@zh-hant
2017年論文
@zh-hk
2017年論文
@zh-mo
2017年論文
@zh-tw
2017年论文
@wuu
2017年论文
@zh
2017年论文
@zh-cn
name
Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.
@en
type
label
Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.
@en
prefLabel
Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.
@en
P2093
P2860
P50
P921
P356
P1476
Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.
@en
P2093
Louis De Muynck
Markus Damme
Paul Saftig
Sander Beel
P2860
P304
P356
10.1093/HMG/DDX162
P577
2017-08-01T00:00:00Z