Reactivation of p53 via MDM2 inhibition. - Wikidata - awgldk - TriplyDB

Reactivation of p53 via MDM2 inhibition.

Reactivation of p53 via MDM2 inhibition.

http://www.wikidata.org/entity/Q38825845

about

MDM2 prevents spontaneous tubular epithelial cell death and acute kidney injury.Zinc-finger proteins in health and disease.MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma.

P2860

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P2860

Reactivation of p53 via MDM2 inhibition.

http://www.wikidata.org/entity/Q38825845

description

2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

@zh-hant

2015年論文

@zh-hk

2015年論文

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2015年論文

@zh-tw

2015年论文

@wuu

2015年论文

@zh

2015年论文

@zh-cn

name

Reactivation of p53 via MDM2 inhibition.

@en

type

label

Reactivation of p53 via MDM2 inhibition.

@en

prefLabel

Reactivation of p53 via MDM2 inhibition.

@en

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P1433

Cell Death and Disease

P1476

Reactivation of p53 via MDM2 inhibition.

@en

P2093

E S Kim

http://www.w3.org/2001/XMLSchema#string

J M Shohet

http://www.w3.org/2001/XMLSchema#string

P2860

Mdm2 promotes the rapid degradation of p53

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

MDM2 small-molecule antagonist RG7112 activates p53 signaling and regresses human tumors in preclinical cancer models

Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development

Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development

Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study.

High Frequency of p53/MDM2/p14ARF Pathway Abnormalities in Relapsed Neuroblastoma.

The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias.

Inhibition of MDM2 by RG7388 confers hypersensitivity to X-radiation in xenograft models of childhood sarcoma.

Initial testing of the MDM2 inhibitor RG7112 by the Pediatric Preclinical Testing Program

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e1936

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scholarly article

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10.1038/CDDIS.2015.302

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P478

6

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P577

2015-10-22T00:00:00Z

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283206787

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26492369

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4632320

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