Identification of DGAT2 Inhibitors Using Mass Spectrometry.

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High-throughput strategies for the discovery and engineering of enzymes for biocatalysis.

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Identification of DGAT2 Inhibitors Using Mass Spectrometry.

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Identification of DGAT2 Inhibitors Using Mass Spectrometry.

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Identification of DGAT2 Inhibitors Using Mass Spectrometry.

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Identification of DGAT2 Inhibitors Using Mass Spectrometry.

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P1476

Identification of DGAT2 Inhibitors Using Mass Spectrometry.

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Andrew Taggart

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Christine Chung

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David G McLaren

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George H Addona

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Jason E Imbriglio

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Jiaping Zhang

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Larissa Wilsie

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Lisa M Sonatore

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Margarita Garcia-Calvo

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Oksana Palyha

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P2860

Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members

Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis

Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance

Lipopenia and skin barrier abnormalities in DGAT2-deficient mice

Knockdown of acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice

Enzymes of glycerolipid synthesis in eukaryotes.

Identification and validation of a selective small molecule inhibitor targeting the diacylglycerol acyltransferase 2 activity.

Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1.

Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis.

The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2

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117-126

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scholarly article

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10.1177/1087057115607463

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P433

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P478

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2015-09-24T00:00:00Z

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26403520

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Identification of DGAT2 Inhibitors Using Mass Spectrometry.

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Identification of DGAT2 Inhibitors Using Mass Spectrometry.

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P433

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