NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling.
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Necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapyPost-translational modifications as key regulators of TNF-induced necroptosisPoly-ubiquitination in TNFR1-mediated necroptosisAn outline of necrosome triggersMK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death.Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell DeathNEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions.TNF activation of NF-κB is essential for development of single-positive thymocytesCaspase-8: not so silently deadly.RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome.Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency.Formation and removal of poly-ubiquitin chains in the regulation of tumor necrosis factor-induced gene activation and cell death.Death receptor 3 mediates necroptotic cell death.SPATA2 promotes CYLD activity and regulates TNF-induced NF-κB signaling and cell death.A real-time fluorometric method for the simultaneous detection of cell death type and rate.Increased miR-155-5p and reduced miR-148a-3p contribute to the suppression of osteosarcoma cell death.Necroptosis-independent signaling by the RIP kinases in inflammation.IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1.Necroptosis: A Novel Cell Death Modality and Its Potential Relevance for Critical Care Medicine.More to Life than NF-κB in TNFR1 SignalingCell death-independent activities of the death receptors CD95, TRAILR1, and TRAILR2.Regulating the balance between necroptosis, apoptosis and inflammation by inhibitors of apoptosis proteins.Roles of Caspases in Necrotic Cell Death.The Inflammatory Signal Adaptor RIPK3: Functions Beyond Necroptosis.Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis.Necroptosis and Cancer.Caspase-8: regulating life and death.The interplay of IKK, NF-κB and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation.Diverse ubiquitin linkages regulate RIP kinases-mediated inflammatory and cell death signaling.Initiation and execution mechanisms of necroptosis: an overview.The small molecule that packs a punch: ubiquitin-mediated regulation of RIPK1/FADD/caspase-8 complexes.Necroptosis in cancer: An angel or a demon?RIPK1-dependent apoptosis bypasses pathogen blockade of innate signaling to promote immune defense.Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury.Necroptosis: Mechanisms and Relevance to Disease.The Linear ubiquitin chain assembly complex acts as a liver tumor suppressor and inhibits hepatocyte apoptosis and hepatitis.p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection.Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis.Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis.Inflammatory factor TNF-α promotes the growth of breast cancer via the positive feedback loop of TNFR1/NF-κB (and/or p38)/p-STAT3/HBXIP/TNFR1.
P2860
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P2860
NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
NF-κB-Independent Role of IKKα ...... ll Death during TNF Signaling.
@en
type
label
NF-κB-Independent Role of IKKα ...... ll Death during TNF Signaling.
@en
prefLabel
NF-κB-Independent Role of IKKα ...... ll Death during TNF Signaling.
@en
P2093
P50
P1433
P1476
NF-κB-Independent Role of IKKα ...... ell Death during TNF Signaling
@en
P2093
Emilie Theatre
Emmanuel Dejardin
John Bertin
Peter J Gough
Piero Giansanti
Tatyana Divert
P356
10.1016/J.MOLCEL.2015.07.032
P577
2015-09-03T00:00:00Z