RG7112, a small-molecule inhibitor of MDM2, enhances trabectedin response in soft tissue sarcomas.

about

Activity of trabectedin and the PARP inhibitor rucaparib in soft-tissue sarcomas Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction.Newer medical therapies for metastatic soft tissue sarcoma.CDK4 inhibition diminishes p53 activation by MDM2 antagonists

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P2860

RG7112, a small-molecule inhibitor of MDM2, enhances trabectedin response in soft tissue sarcomas.

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2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

RG7112, a small-molecule inhib ...... ponse in soft tissue sarcomas.

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RG7112, a small-molecule inhib ...... ponse in soft tissue sarcomas.

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RG7112, a small-molecule inhib ...... ponse in soft tissue sarcomas.

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P1476

RG7112, a small-molecule inhib ...... ponse in soft tissue sarcomas.

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P2093

Antònia Obrador-Hevia

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Esther Martinez-Font

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Irene Felipe-Abrio

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José Antonio López-Guerrero

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Margalida Serra-Sitjar

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Rafael Ramos

http://www.w3.org/2001/XMLSchema#string

Regina Alemany

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P2860

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

MDM2 small-molecule antagonist RG7112 activates p53 signaling and regresses human tumors in preclinical cancer models

A systems biology approach to characterize the regulatory networks leading to trabectedin resistance in an in vitro model of myxoid liposarcoma

Nilotinib counteracts P-glycoprotein-mediated multidrug resistance and synergizes the antitumoral effect of doxorubicin in soft tissue sarcomas

Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair.

Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action.

Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study.

MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines.

Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells.

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440-450

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scholarly article

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10.3109/07357907.2015.1064534

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P478

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Silvia Calabuig-Fariñas

Javier Martín-Broto

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2015-08-14T00:00:00Z

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281143787

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26288114

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RG7112, a small-molecule inhibitor of MDM2, enhances trabectedin response in soft tissue sarcomas.

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P2860

P2860

RG7112, a small-molecule inhibitor of MDM2, enhances trabectedin response in soft tissue sarcomas.

description

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