Cellular Accumulation and Toxic Effects of Bile Acids in Cyclosporine A-Treated HepaRG Hepatocytes. - Wikidata - awgldk - TriplyDB

Cellular Accumulation and Toxic Effects of Bile Acids in Cyclosporine A-Treated HepaRG Hepatocytes.

Cellular Accumulation and Toxic Effects of Bile Acids in Cyclosporine A-Treated HepaRG Hepatocytes.

http://www.wikidata.org/entity/Q38850691

about

Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs.Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans Penicillinase-resistant antibiotics induce non-immune-mediated cholestasis through HSP27 activation associated with PKC/P38 and PI3K/AKT signaling pathways Functional human induced hepatocytes (hiHeps) with bile acid synthesis and transport capacities: A novel in vitro cholestatic model.A Dynamic Mathematical Model of Bile Acid Clearance in HepaRG Cells.Identification of functional farnesoid X receptors in brain neurons.From the Cover: MechanisticInsights in Cytotoxic and Cholestatic Potential of the Endothelial Receptor Antagonists Using HepaRG Cells.Early Alterations of Bile Canaliculi Dynamics and the Rho Kinase/Myosin Light Chain Kinase Pathway Are Characteristics of Drug-Induced Intrahepatic Cholestasis.Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures

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P2860

Cellular Accumulation and Toxic Effects of Bile Acids in Cyclosporine A-Treated HepaRG Hepatocytes.

http://www.wikidata.org/entity/Q38850691

description

2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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2015年论文

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name

Cellular Accumulation and Toxi ...... A-Treated HepaRG Hepatocytes.

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type

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Cellular Accumulation and Toxi ...... A-Treated HepaRG Hepatocytes.

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Cellular Accumulation and Toxi ...... A-Treated HepaRG Hepatocytes.

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Toxicological Sciences

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Cellular Accumulation and Toxi ...... A-Treated HepaRG Hepatocytes.

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P2093

Ahmad Sharanek

http://www.w3.org/2001/XMLSchema#string

Andre Guillouzo

http://www.w3.org/2001/XMLSchema#string

Audrey Burban

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Dominique Rainteau

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Lydie Humbert

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Neuza Felix-Gomes

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Pamela Bachour-El Azzi

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P2860

Bile acid transporters

Bile acids: regulation of synthesis

The bile salt export pump

Enterohepatic bile salt transporters in normal physiology and liver disease

Interindividual variability in gene expression profiles in human hepatocytes and comparison with HepaRG cells.

Bile salt transporters: molecular characterization, function, and regulation.

Drug-induced hepatotoxicity.

Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease.

Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations.

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

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573-587

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scholarly article

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10.1093/TOXSCI/KFV155

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2

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147

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2015-07-20T00:00:00Z

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26198044

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