Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX. - Wikidata - awgldk - TriplyDB

Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX.

Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX.

http://www.wikidata.org/entity/Q38856558

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Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies Telomere biology: Rationale for diagnostics and therapeutics in cancer The Role of ATRX in the Alternative Lengthening of Telomeres (ALT) Phenotype ATRX binds to atypical chromatin domains at the 3' exons of zinc finger genes to preserve H3K9me3 enrichment Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands.Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres.Epigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in Gliomas.Telomere Biology-Insights into an Intriguing Phenomenon.Mre11 and Blm-Dependent Formation of ALT-Like Telomeres in Ku-Deficient Ustilago maydis.Massively parallel sequencing of phyllodes tumours of the breast reveals actionable mutations, and TERT promoter hotspot mutations and TERT gene amplification as likely drivers of progression Inactivating ARID1A Tumor Suppressor Enhances TERT Transcription and Maintains Telomere Length in Cancer Cells.Switch telomerase to ALT mechanism by inducing telomeric DNA damages and dysfunction of ATRX and DAXX.Mutated Chromatin Regulatory Factors as Tumor Drivers in Cancer Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids Stop pulling my strings - what telomeres taught us about the DNA damage response.The Diagnostic Use of Immunohistochemical Surrogates for Signature Molecular Genetic Alterations in Gliomas.FANCD2 limits BLM-dependent telomere instability in the alternative lengthening of telomeres pathway.The chromatin remodelling factor ATRX suppresses R-loops in transcribed telomeric repeats.Telomere recombination pathways: tales of several unhappy marriages.ATRX and DAXX: Mechanisms and Mutations.Solving the Telomere Replication Problem.The Telomeric Response to Viral Infection.Cancer Cells with Alternative Lengthening of Telomeres Do Not Display a General Hypersensitivity to ATR Inhibition.Systematic analysis of telomere length and somatic alterations in 31 cancer types.ATRX is a regulator of therapy induced senescence in human cells.Multifunctional adaptor protein Daxx interacts with chromatin-remodelling ATPase Brg1.Stalled replication forks within heterochromatin require ATRX for protection.The Role of ATRX in Glioma Biology.Diagnosis and treatment of ALT tumors: is Trabectedin a new therapeutic option?Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway.Integrative genomic and transcriptomic analysis of leiomyosarcoma.Telomere chromatin establishment and its maintenance during mammalian development.dAdd1 and dXNP prevent genome instability by maintaining HP1a localization at Drosophila telomeres.Effect of ATRX and G-Quadruplex Formation by the VNTR Sequence on α-Globin Gene Expression.TERRA RNA Antagonizes ATRX and Protects Telomeres.ALK in Neuroblastoma: Biological and Therapeutic Implications.Genomic origin and nuclear localization of TERRA telomeric repeat-containing RNA: from Darkness to Dawn.Reconstructing the molecular life history of gliomas.Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling.Aberrant ATRX protein expression is associated with poor overall survival in NF1-MPNST.

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Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX.

http://www.wikidata.org/entity/Q38856558

description

2015 nî lūn-bûn

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2015年の論文

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年學術文章

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2015年學術文章

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2015年學術文章

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Suppression of the alternative ...... matin remodelling factor ATRX.

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Suppression of the alternative ...... matin remodelling factor ATRX.

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Suppression of the alternative ...... matin remodelling factor ATRX.

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Suppression of the alternative ...... matin remodelling factor ATRX.

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P2093

Barbara Xella

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Caroline Scott

http://www.w3.org/2001/XMLSchema#string

Clare Jelinska

http://www.w3.org/2001/XMLSchema#string

Helena Ayyub

http://www.w3.org/2001/XMLSchema#string

Matthew Mitson

http://www.w3.org/2001/XMLSchema#string

Stephen Taylor

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P2860

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres

Suppression of alternative lengthening of telomeres by Sp100-mediated sequestration of the MRE11/RAD50/NBS1 complex.

Mutations in a putative global transcriptional regulator cause X-linked mental retardation with alpha-thalassemia (ATR-X syndrome)

The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3

ATRX dysfunction induces replication defects in primary mouse cells

Saccharomyces cerevisiae Mre11 is a high-affinity G4 DNA-binding protein and a G-rich DNA-specific endonuclease: implications for replication of telomeric DNA

ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells

Distinct factors control histone variant H3.3 localization at specific genomic regions

DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors

A guided tour into subcellular colocalization analysis in light microscopy

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10.1038/NCOMMS8538

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6

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Richard J Gibbons

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2015-07-06T00:00:00Z

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