Plk1 and Mps1 Cooperatively Regulate the Spindle Assembly Checkpoint in Human Cells.
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The Functional Significance of Posttranslational Modifications on Polo-Like Kinase 1 Revealed by Chemical Genetic ComplementationCentrosome - a promising anti-cancer targetMitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical UtilityA Centromere-Signaling Network Underlies the Coordination among Mitotic EventsTumor suppressor protein DAB2IP participates in chromosomal stability maintenance through activating spindle assembly checkpoint and stabilizing kinetochore-microtubule attachments.Centrin 3 is an inhibitor of centrosomal Mps1 and antagonizes centrin 2 function.Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability.Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpointProbing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524.Whole-genome duplication increases tumor cell sensitivity to MPS1 inhibition.Mitotic phosphatase activity is required for MCC maintenance during the spindle checkpoint.How the SAC gets the axe: Integrating kinetochore microtubule attachments with spindle assembly checkpoint signaling.Quantitative analysis of human centrosome architecture by targeted proteomics and fluorescence imaging.Aurora-A promotes the establishment of spindle assembly checkpoint by priming the Haspin-Aurora-B feedback loop in late G2 phase.Therapeutic relevance of the protein phosphatase 2A in cancer.Plk1 Inhibitors in Cancer Therapy: From Laboratory to Clinics.Playing polo during mitosis: PLK1 takes the lead.Whole Exome Sequencing Identify the 6q12-q16 Linkage Region and a Candidate Gene TTK for Pulmonary Nontuberculous Mycobacterial Disease.The Fungal Metabolite Brefeldin A Inhibits Dvl2-Plk1-Dependent Primary Cilium DisassemblyPlk1 bound to Bub1 contributes to spindle assembly checkpoint activity during mitosis.Meikin-associated polo-like kinase specifies Bub1 distribution in meiosis I.The PP2AB56 phosphatase promotes the association of Cdc20 with APC/C in mitosis.Plk1 inhibition leads to a failure of mitotic division during the first mitotic division in pig embryos.Mechanisms of Mitotic Kinase Regulation: A Structural Perspective.Lateral attachment of kinetochores to microtubules is enriched in prometaphase rosette and facilitates chromosome alignment and bi-orientation establishment.PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells.Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint.A Kinase-Phosphatase Network that Regulates Kinetochore-Microtubule Attachments and the SAC.Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis.MAD1: Kinetochore Receptors and Catalytic Mechanisms.Kinase and Phosphatase Cross-Talk at the Kinetochore.Leader of the SAC: molecular mechanisms of Mps1/TTK regulation in mitosis
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P2860
Plk1 and Mps1 Cooperatively Regulate the Spindle Assembly Checkpoint in Human Cells.
description
2015 nî lūn-bûn
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2015年の論文
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年學術文章
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2015年學術文章
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2015年學術文章
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name
Plk1 and Mps1 Cooperatively Regulate the Spindle Assembly Checkpoint in Human Cells.
@en
type
label
Plk1 and Mps1 Cooperatively Regulate the Spindle Assembly Checkpoint in Human Cells.
@en
prefLabel
Plk1 and Mps1 Cooperatively Regulate the Spindle Assembly Checkpoint in Human Cells.
@en
P2093
P50
P1433
P1476
Plk1 and Mps1 Cooperatively Regulate the Spindle Assembly Checkpoint in Human Cells.
@en
P2093
Conrad von Schubert
Geert J P L Kops
Jasmine M Bracher
Tale Sliedrecht
P356
10.1016/J.CELREP.2015.06.007
P577
2015-06-25T00:00:00Z