Inhibition of HIV-1 by lentiviral vector-transduced siRNAs in T lymphocytes differentiated in SCID-hu mice and CD34+ progenitor cell-derived macrophages.
about
Substitution of the Rev-response element in an HIV-1-based gene delivery system with that of SIVmac239 allows efficient delivery of Rev M10 into T-lymphocytes.T cell-specific siRNA delivery suppresses HIV-1 infection in humanized miceHIV-1 resistance conferred by siRNA cosuppression of CXCR4 and CCR5 coreceptors by a bispecific lentiviral vectorLentiviral transduction of Tar Decoy and CCR5 ribozyme into CD34+ progenitor cells and derivation of HIV-1 resistant T cells and macrophagesCXCR4 and CCR5 shRNA transgenic CD34+ cell derived macrophages are functionally normal and resist HIV-1 infectionGene therapy strategies for HIV/AIDS: preclinical modeling in humanized miceInhibition of west nile virus replication by retrovirus-delivered small interfering RNA in human neuroblastoma cellsIdentification of cellular cofactors for human immunodeficiency virus replication via a ribozyme-based genomics approachHIV-1-based defective lentiviral vectors efficiently transduce human monocytes-derived macrophages and suppress replication of wild-type HIV-1RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma.Unlocking the potential of the human genome with RNA interference.Antiviral effects of human immunodeficiency virus type 1-specific small interfering RNAs against targets conserved in select neurotropic viral strains.Lentiviral-mediated delivery of siRNAs for antiviral therapy.The interplay between virus infection and the cellular RNA interference machinery.RNAi therapeutics: principles, prospects and challenges.Effective suppression of human immunodeficiency virus type 1 through a combination of short- or long-hairpin RNAs targeting essential sequences for retroviral integration.Thymic plasmacytoid dendritic cells are susceptible to productive HIV-1 infection and efficiently transfer R5 HIV-1 to thymocytes in vitroInhibition of HIV-1 infection by a unique short hairpin RNA to chemokine receptor 5 delivered into macrophages through hematopoietic progenitor cell transductionGene silencing of HIV-1 by RNA interference.RNA interference: a potent tool for gene-specific therapeutics.Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIVApplication of RNA interference to study stem cell function: current status and future perspectives.Antiviral RNAi therapy: emerging approaches for hitting a moving target.Enhancing siRNA effects in T cells for adoptive immunotherapy.Instability of retroviral vectors with HIV-1-specific RT aptamers due to cryptic splice sites in the U6 promoter.Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors.Exploitation of stem cell homing for gene delivery.Humanized mouse models of HIV infectionExpression strategies for short hairpin RNA interference triggers.A novel approach for inhibition of HIV-1 by RNA interference: counteracting viral escape with a second generation of siRNAs.Lipid-based systemic delivery of siRNA.Lentiviral delivery of short hairpin RNAsRNA-interference-based gene therapy approaches to HIV type-1 treatment: tackling the hurdles from bench to bedside.RNA interference-based therapeutics for human immunodeficiency virus HIV-1 treatment: synthetic siRNA or vector-based shRNA?HIV-1 evolution: frustrating therapies, but disclosing molecular mechanisms.Possible applications for replicating HIV 1 vectorsApplication of RNA interference in treating human diseases.RNA interference--a silent but an efficient therapeutic tool.Transfer and Expression of Small Interfering RNAs in Mammalian Cells Using Lentiviral VectorsRNAi Technique in Stem Cell Research: Current Status and Future Perspectives.
P2860
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P2860
Inhibition of HIV-1 by lentiviral vector-transduced siRNAs in T lymphocytes differentiated in SCID-hu mice and CD34+ progenitor cell-derived macrophages.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Inhibition of HIV-1 by lentivi ...... itor cell-derived macrophages.
@en
type
label
Inhibition of HIV-1 by lentivi ...... itor cell-derived macrophages.
@en
prefLabel
Inhibition of HIV-1 by lentivi ...... itor cell-derived macrophages.
@en
P2093
P1433
P1476
Inhibition of HIV-1 by lentivi ...... itor cell-derived macrophages.
@en
P2093
Gerhard Bauer
John Rossi
Leila Remling
Ming-Jie Li
Nan-Sook Lee
Ramesh Akkina
P356
10.1016/S1525-0016(03)00140-0
P577
2003-07-01T00:00:00Z