Targeting the MLL complex in castration-resistant prostate cancer. - Wikidata - awgldk - TriplyDB

Targeting the MLL complex in castration-resistant prostate cancer.

Targeting the MLL complex in castration-resistant prostate cancer.

http://www.wikidata.org/entity/Q38893281

about

One-Carbon Metabolism in Prostate Cancer: The Role of Androgen Signaling Persistent androgen receptor addiction in castration-resistant prostate cancer Insights into Chemoresistance of Prostate Cancer Epigenetic determinants of metastasis Disruption of serine/threonine protein phosphatase 5 inhibits tumorigenesis of urinary bladder cancer cells Whole-Genome Sequence of the Metastatic PC3 and LNCaP Human Prostate Cancer Cell Lines.Functional and therapeutic significance of EZH2 in urological cancers MLL1 is essential for the senescence-associated secretory phenotype The Landscape of microRNA Targeting in Prostate Cancer Defined by AGO-PAR-CLIP.ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer.BAP18 coactivates androgen receptor action and promotes prostate cancer progression.Long noncoding RNA DANCR promotes invasion of prostate cancer through epigenetically silencing expression of TIMP2/3 AR-Signaling in Human Malignancies: Prostate Cancer and Beyond.Tumorigenicity of Ewing sarcoma is critically dependent on the trithorax proteins MLL1 and menin.Drugging Chromatin in Cancer: Recent Advances and Novel Approaches.Twenty years of menin: emerging opportunities for restoration of transcription in MEN1.MTA1-activated Epi-microRNA-22 regulates E-cadherin and prostate cancer invasiveness.Chromatin remodelling and DNA repair genes are frequently mutated in endometrioid endometrial carcinoma.The emerging role of PI3K/AKT-mediated epigenetic regulation in cancer.SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes.Targeting persistent androgen receptor signaling in castration-resistant prostate cancer.Enhancer-Mediated Oncogenic Function of the Menin Tumor Suppressor in Breast Cancer.Rationale for the development of alternative forms of androgen deprivation therapy.Global analysis of transcription in castration-resistant prostate cancer cells uncovers active enhancers and direct androgen receptor targets.KAT8 Regulates Androgen Signaling in Prostate Cancer Cells.miR-618 Inhibits Prostate Cancer Migration and Invasion by Targeting FOXP2.Development and Use of Assay Conditions Suited to Screening for and Profiling of SET-Domain-Targeted Inhibitors of the MLL/SET1 Family of Lysine Methyltransferases.Alterations of androgen receptor-regulated enhancer RNAs (eRNAs) contribute to enzalutamide resistance in castration-resistant prostate cancer.ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor.Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer.Oral administration of withaferin A inhibits carcinogenesis of prostate in TRAMP model.LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis.Salen-Mn compounds induces cell apoptosis in human prostate cancer cells through promoting AMPK activity and cell autophagy.Molecular determinants of prostate cancer metastasis.Determining direct binders of the Androgen Receptor using a high-throughput Cellular Thermal Shift Assay.Nuclear receptors in cancer - uncovering new and evolving roles through genomic analysis.Pharmacologic Inhibition of the Menin-MLL Interaction Leads to Transcriptional Repression of PEG10 and Blocks Hepatocellular Carcinoma.The future: genetics advances in MEN1 therapeutic approaches and management strategies.BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1.Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy.

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Targeting the MLL complex in castration-resistant prostate cancer.

http://www.wikidata.org/entity/Q38893281

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2015 nî lūn-bûn

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2015年の論文

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年學術文章

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2015年學術文章

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2015年學術文章

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Targeting the MLL complex in castration-resistant prostate cancer.

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Targeting the MLL complex in castration-resistant prostate cancer.

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Targeting the MLL complex in castration-resistant prostate cancer.

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Nature Medicine

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Targeting the MLL complex in castration-resistant prostate cancer.

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Amjad P Khan

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Anastasia K Yocum

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Arul M Chinnaiyan

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Dmitry Borkin

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Felix Y Feng

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Jolanta Grembecka

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June Escara-Wilke

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Lakshmi P Kunju

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Matthew K Iyer

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Pranathi M Krishnamurthy

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P2860

Global cancer statistics

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression

Identification of the MLL2 complex as a coactivator for estrogen receptor alpha

Development of a second-generation antiandrogen for treatment of advanced prostate cancer

Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction

Molecular determinants of resistance to antiandrogen therapy

ONCOMINE: a cancer microarray database and integrated data-mining platform

Positional cloning of the gene for multiple endocrine neoplasia-type 1

MEME SUITE: tools for motif discovery and searching

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10.1038/NM.3830

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John R. Prensner

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Dattatreya Mellacheruvu

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