Phosphorylation of eIF2α triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma.
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Endoplasmic reticulum stress-mediated pathways to both apoptosis and autophagy: Significance for melanoma treatmentQuantitative phosphoproteomics reveals new roles for the protein phosphatase PP6 in mitotic cellsThe E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acidsCorrelation of histopathologic characteristics to protein expression and function in malignant melanoma.Adaptation of HepG2 cells to a steady-state reduction in the content of protein phosphatase 6 (PP6) catalytic subunitInadequate fine-tuning of protein synthesis and failure of amino acid homeostasis following inhibition of the ATPase VCP/p97mTORC1 and CK2 coordinate ternary and eIF4F complex assembly.Crosstalk between cystine and glutathione is critical for the regulation of amino acid signaling pathways and ferroptosisCellular adaptation to nutrient deprivation: crosstalk between the mTORC1 and eIF2α signaling pathways and implications for autophagy.Synergistic inhibition of cell proliferation by combined targeting with kinase inhibitors and dietary xanthone is a promising strategy for melanoma treatment.Cross-talk between protein synthesis, energy metabolism and autophagy in cancer.Dysregulation of mRNA translation and energy metabolism in cancer.Autophagy contributes to sulfonylurea herbicide tolerance via GCN2-independent regulation of amino acid homeostasis.Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells.HRI-mediated translational repression reduces proteotoxicity and sensitivity to bortezomib in human pancreatic cancer cells.Signaling pathways involved in the regulation of mRNA translation.Molecular Pathways in Melanomagenesis: What We Learned from Next-Generation Sequencing Approaches
P2860
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P2860
Phosphorylation of eIF2α triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
Phosphorylation of eIF2α trigg ...... rant in PP6C-mutated melanoma.
@en
type
label
Phosphorylation of eIF2α trigg ...... rant in PP6C-mutated melanoma.
@en
prefLabel
Phosphorylation of eIF2α trigg ...... rant in PP6C-mutated melanoma.
@en
P2093
P2860
P1433
P1476
Phosphorylation of eIF2α trigg ...... rant in PP6C-mutated melanoma.
@en
P2093
Iman Osman
Jordan Wengrod
Sarah Weiss
P2860
P356
10.1126/SCISIGNAL.AAA0899
P577
2015-03-10T00:00:00Z