Protease Inhibitors Block Multiple Functions of the NS3/4A Protease-Helicase during the Hepatitis C Virus Life Cycle. - Wikidata - awgldk - TriplyDB

Protease Inhibitors Block Multiple Functions of the NS3/4A Protease-Helicase during the Hepatitis C Virus Life Cycle.

Protease Inhibitors Block Multiple Functions of the NS3/4A Protease-Helicase during the Hepatitis C Virus Life Cycle.

http://www.wikidata.org/entity/Q38903369

about

Modelling hepatitis C therapy--predicting effects of treatment Natural HCV variants with increased replicative fitness due to NS3 helicase mutations in the C-terminal helix α18 NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains.Rad51 Interacts with Non-structural 3 Protein of Hepatitis C Virus and Regulates Viral Production Identification of a resveratrol tetramer as a potent inhibitor of hepatitis C virus helicase.Hepatitis C Virus Genotype 1 to 6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness, and Resistance Patterns in the Context of the Infectious Viral Life Cycle.Evaluation of antiviral drug synergy in an infectious HCV system.NS3 from Hepatitis C Virus Strain JFH-1 Is an Unusually Robust Helicase That Is Primed To Bind and Unwind Viral RNA.Viral Oncology: Molecular Biology and Pathogenesis.Pharmacophore feature prediction and molecular docking approach to identify novel anti-HCV protease inhibitors.Sofosbuvir + velpatasvir + voxilaprevir for the treatment of hepatitis C infection.Unexpected Replication Boost by Simeprevir for Simeprevir-resistant Variants in Genotype 1a Hepatitis C Virus.

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P2860

Protease Inhibitors Block Multiple Functions of the NS3/4A Protease-Helicase during the Hepatitis C Virus Life Cycle.

http://www.wikidata.org/entity/Q38903369

description

2015 nî lūn-bûn

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2015年の論文

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年學術文章

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2015年學術文章

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2015年學術文章

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name

Protease Inhibitors Block Mult ...... Hepatitis C Virus Life Cycle.

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type

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Protease Inhibitors Block Mult ...... Hepatitis C Virus Life Cycle.

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prefLabel

Protease Inhibitors Block Mult ...... Hepatitis C Virus Life Cycle.

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Journal of Virology

P1476

Protease Inhibitors Block Mult ...... Hepatitis C Virus Life Cycle.

@en

P2093

Brent Graham

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Chris Hamlett

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Susanne Saalau-Bethell

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Takahiro Masaki

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William Lovell

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P2860

Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity

In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor

Regulation of hepatic innate immunity by hepatitis C virus

Hyperphosphorylation of the hepatitis C virus NS5A protein requires an active NS3 protease, NS4A, NS4B, and NS5A encoded on the same polyprotein

The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding.

Hepatitis C virus subgenomic replicon requires an active NS3 RNA helicase.

SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cells.

VX-950, a Novel Hepatitis C Virus (HCV) NS3-4A Protease Inhibitor, Exhibits Potent Antiviral Activities in HCV Replicon Cells

Polynucleotide modulation of the protease, nucleoside triphosphatase, and helicase activities of a hepatitis C virus NS3-NS4A complex isolated from transfected COS cells

NS3 Helicase Domains Involved in Infectious Intracellular Hepatitis C Virus Particle Assembly

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5362-5370

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scholarly article

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10.1128/JVI.03188-14

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10

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89

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David R. McGivern

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2015-03-04T00:00:00Z

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25740995

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4442512

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