about
Cognitive reserve and TMEM106B genotype modulate brain damage in presymptomatic frontotemporal dementia: a GENFI study.Subcellular Trafficking of Mammalian Lysosomal Proteins: An Extended View.C9orf72: At the intersection of lysosome cell biology and neurodegenerative disease.DCTN1-related neurodegeneration: Perry syndrome and beyond.Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations.The role of gene variants in the pathogenesis of neurodegenerative disorders as revealed by next generation sequencing studies: a review.A recurrent de novo mutation in TMEM106B causes hypomyelinating leukodystrophy.The TMEM106B risk allele is associated with lower cortical volumes in a clinically diagnosed frontotemporal dementia cohort.TMEM106B and myelination: rare leukodystrophy families reveal unexpected connections.Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity.TMEM106B haplotypes have distinct gene expression patterns in aged brain.TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins.
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description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年学术文章
@wuu
2016年学术文章
@zh-cn
2016年学术文章
@zh-hans
2016年学术文章
@zh-my
2016年学术文章
@zh-sg
2016年學術文章
@yue
2016年學術文章
@zh
2016年學術文章
@zh-hant
name
What we know about TMEM106B in neurodegeneration.
@en
type
label
What we know about TMEM106B in neurodegeneration.
@en
prefLabel
What we know about TMEM106B in neurodegeneration.
@en
P2860
P1476
What we know about TMEM106B in neurodegeneration.
@en
P2093
Alexandra M Nicholson
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P2888
P304
P356
10.1007/S00401-016-1610-9
P577
2016-08-20T00:00:00Z
P6179
1043939645