Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.

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Pathogenic PS1 phosphorylation at Ser367 Bidirectional regulation of Aβ levels by Presenilin 1.Twenty Years of Presenilins--Important Proteins in Health and Disease.Regulated intramembrane proteolysis: emergent role in cell signalling pathways.Versatility of presenilin 1.

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P2860

Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.

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http://www.wikidata.org/entity/Q38933827

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2015 nî lūn-bûn

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2015年の論文

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年學術文章

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2015年學術文章

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2015年學術文章

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name

Identification of new Presenil ...... se activity and Aβ production.

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type

Item

label

Identification of new Presenil ...... se activity and Aβ production.

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prefLabel

Identification of new Presenil ...... se activity and Aβ production.

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P1476

Identification of new Presenil ...... se activity and Aβ production.

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Alexandre Matz

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Blanka Halamoda-Kenzaoui

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Jean-René Alattia

http://www.w3.org/2001/XMLSchema#string

Mitko Dimitrov

http://www.w3.org/2001/XMLSchema#string

Romain Hamelin

http://www.w3.org/2001/XMLSchema#string

Sebastien Mosser

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P2860

Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates

Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

A nine-transmembrane domain topology for presenilin 1

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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409-421

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scholarly article

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10.1111/JNC.12996

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English

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133

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Patrick C Fraering

Marc Moniatte

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2015-02-24T00:00:00Z

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25458374

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Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.

about

P2860

P2860

Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.

description

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type

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P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698