Vav1 promotes lung cancer growth by instigating tumor-microenvironment cross-talk via growth factor secretion.

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Vav1: A Dr. Jekyll and Mr. Hyde protein--good for the hematopoietic system, bad for cancer Clinical significance and prognostic value of Vav1 expression in Non-small cell lung cancer.TGFβ promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1.

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Vav1 promotes lung cancer growth by instigating tumor-microenvironment cross-talk via growth factor secretion.

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2014 nî lūn-bûn

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Vav1 promotes lung cancer grow ...... k via growth factor secretion.

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Item

label

Vav1 promotes lung cancer grow ...... k via growth factor secretion.

@en

prefLabel

Vav1 promotes lung cancer grow ...... k via growth factor secretion.

@en

P1476

Vav1 promotes lung cancer grow ...... k via growth factor secretion.

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Galit Lazer

http://www.w3.org/2001/XMLSchema#string

Marganit Farago

http://www.w3.org/2001/XMLSchema#string

Shiran Rabinovich

http://www.w3.org/2001/XMLSchema#string

Shulamit Katzav

http://www.w3.org/2001/XMLSchema#string

Shulamit Sebban

http://www.w3.org/2001/XMLSchema#string

Yulia Idelchuck

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vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells

Cell signaling by receptor tyrosine kinases

Synthesis of membrane-bound colony-stimulating factor 1 (CSF-1) and downmodulation of CSF-1 receptors in NIH 3T3 cells transformed by cotransfection of the human CSF-1 and c-fms (CSF-1 receptor) genes

Signal transduction by receptors with tyrosine kinase activity

Vav is associated with signal transducing molecules gp130, Grb2 and Erk2, and is tyrosine phosphorylated in response to interleukin-6

Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis

Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs

Dynamin 2 potentiates invasive migration of pancreatic tumor cells through stabilization of the Rac1 GEF Vav1

An active form of Vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligand

Colony-stimulating factor-1 stimulates the formation of multimeric cytosolic complexes of signaling proteins and cytoskeletal components in macrophages.

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9214-9226

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scholarly article

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10.18632/ONCOTARGET.2400

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English

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Lena Ilan

eli pikarsky

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2014-10-01T00:00:00Z

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266944325

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25313137

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P932

4253429

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Vav1 promotes lung cancer growth by instigating tumor-microenvironment cross-talk via growth factor secretion.

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P2860

Vav1 promotes lung cancer growth by instigating tumor-microenvironment cross-talk via growth factor secretion.

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