PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways.
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Mechanistic Insights into Molecular Targeting and Combined Modality Therapy for Aggressive, Localized Prostate CancerCancer stem cells and signaling pathways in radioresistanceTherapeutic Implications for Overcoming Radiation Resistance in Cancer TherapyDownregulation of Annexin A1 is correlated with radioresistance in nasopharyngeal carcinoma.Akt/mTOR mediated induction of bystander effect signaling in a nucleus independent manner in irradiated human lung adenocarcinoma epithelial cells.Inhibiting DNA-PKcs in a non-homologous end-joining pathway in response to DNA double-strand breaks.Tumor cells switch to mitochondrial oxidative phosphorylation under radiation via mTOR-mediated hexokinase II inhibition--a Warburg-reversing effectNonautophagic cytoplasmic vacuolation death induction in human PC-3M prostate cancer by curcumin through reactive oxygen species -mediated endoplasmic reticulum stressLRIG1 enhances the radiosensitivity of radioresistant human glioblastoma U251 cells via attenuation of the EGFR/Akt signaling pathway.Targeting WISP1 to sensitize esophageal squamous cell carcinoma to irradiation.Radio-sensitization effect of an mTOR inhibitor, temsirolimus, on lung adenocarcinoma A549 cells under normoxic and hypoxic conditions.Metformin Radiosensitizes p53-Deficient Colorectal Cancer Cells through Induction of G2/M Arrest and Inhibition of DNA Repair Proteins.Silencing NFBD1/MDC1 enhances the radiosensitivity of human nasopharyngeal cancer CNE1 cells and results in tumor growth inhibition.Atg3 Overexpression Enhances Bortezomib-Induced Cell Death in SKM-1 CellmiR-195 Inhibits Tumor Progression by Targeting RPS6KB1 in Human Prostate Cancer.TP53inp1 Gene Is Implicated in Early Radiation Response in Human Fibroblast Cells.Koschei the immortal and anti-aging drugsRadiosensitizing effect of diosmetin on radioresistant lung cancer cells via Akt signaling pathway.Arenobufagin intercalates with DNA leading to G2 cell cycle arrest via ATM/ATR pathway.p73 regulates basal and starvation-induced liver metabolism in vivo.RHAMM splice variants confer radiosensitivity in human breast cancer cell linesComplement-Mediated Regulation of Metabolism and Basic Cellular ProcessesAcquired resistance to combination treatment through loss of synergy with MEK and PI3K inhibitors in colorectal cancer.Gli-1/PI3K/AKT/NF-kB pathway mediates resistance to radiation and is a target for reversion of responses in refractory acute myeloid leukemia cells.The kinome pathways in radioresistance breast cancer stem cells.Dual targeting of PI3K and MEK enhances the radiation response of K-RAS mutated non-small cell lung cancer.Identification of protein biomarkers and signaling pathways associated with prostate cancer radioresistance using label-free LC-MS/MS proteomic approach.Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cellsRetrospective growth kinetics and radiosensitivity analysis of various human xenograft models.The PI3K/mTOR dual inhibitor BEZ235 suppresses proliferation and migration and reverses multidrug resistance in acute myeloid leukemia.Knockdown of NFBD1/MDC1 enhances chemosensitivity to cisplatin or 5-fluorouracil in nasopharyngeal carcinoma CNE1 cells.Hypoxia-Responsive Mir-301a and Mir-301b Promote Radioresistance of Prostate Cancer Cells via Downregulating NDRG2.MicroRNA-495 Regulates Migration and Invasion in Prostate Cancer Cells Via Targeting Akt and mTOR Signaling.Inhibition of mTOR enhances radiosensitivity of lung cancer cells and protects normal lung cells against radiation.Deconvoluting the relationships between autophagy and metastasis for potential cancer therapy.Ursolic Acid Induces Apoptosis of Prostate Cancer Cells via the PI3K/Akt/mTOR Pathway.Curcumin sensitizes prostate cancer cells to radiation partly via epigenetic activation of miR-143 and miR-143 mediated autophagy inhibition.The role of autophagy in the cytotoxicity induced by recombinant human arginase in laryngeal squamous cell carcinoma.Sulfoquinovosylacylpropanediol is a novel potent radiosensitizer in prostate cancer.Enhanced dependency of KRAS-mutant colorectal cancer cells on RAD51-dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae.
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P2860
PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
PI3K/Akt/mTOR pathway inhibito ...... g NHEJ and HR repair pathways.
@en
type
label
PI3K/Akt/mTOR pathway inhibito ...... g NHEJ and HR repair pathways.
@en
prefLabel
PI3K/Akt/mTOR pathway inhibito ...... g NHEJ and HR repair pathways.
@en
P2093
P2860
P356
P1476
PI3K/Akt/mTOR pathway inhibito ...... g NHEJ and HR repair pathways.
@en
P2093
P2860
P2888
P356
10.1038/CDDIS.2014.415
P577
2014-10-02T00:00:00Z
P5875
P6179
1051727150