Mechanistic pharmacokinetic/pharmacodynamic modeling of in vivo tumor uptake, catabolism, and tumor response of trastuzumab maytansinoid conjugates.
about
Integrated PK-PD and agent-based modeling in oncologyEvolution of Antibody-Drug Conjugate Tumor Disposition Model to Predict Preclinical Tumor Pharmacokinetics of Trastuzumab-Emtansine (T-DM1).Determination of Cellular Processing Rates for a Trastuzumab-Maytansinoid Antibody-Drug Conjugate (ADC) Highlights Key Parameters for ADC Design.Integration of bioanalytical measurements using PK-PD modeling and simulation: implications for antibody-drug conjugate development.Development of a Translational Physiologically Based Pharmacokinetic Model for Antibody-Drug Conjugates: a Case Study with T-DM1.New Insights in Tissue Distribution, Metabolism, and Excretion of [3H]-Labeled Antibody Maytansinoid Conjugates in Female Tumor-Bearing Nude Rats.Antibody-drug conjugates nonclinical support: from early to late nonclinical bioanalysis using ligand-binding assays.Antibody-Drug Conjugates: Pharmacokinetic/Pharmacodynamic Modeling, Preclinical Characterization, Clinical Studies, and Lessons Learned.Antibody-drug conjugate bioanalysis using LB-LC-MS/MS hybrid assays: strategies, methodology and correlation to ligand-binding assays.Antibody-conjugated drug assay for protease-cleavable antibody-drug conjugates.
P2860
Q27006577-12065A79-8D03-4D23-B3DA-E8654ACDD73CQ37585671-D10EB20C-3E48-41D5-ADDD-8DC2DF88A1B9Q37600390-B6065785-647E-4D67-B134-7F8A922E328CQ38557522-7BC23050-4531-4B6C-B115-390FFCA61A8AQ38624597-2574558D-3CF6-48FE-8333-5E15A96C1E40Q39815639-D0EA43C3-6D9D-4665-A947-D53C3EEBD127Q40677785-88D2747A-90E2-4FD8-AC18-F36B5BBE9F8BQ46209550-1C2AA8C4-C8EE-4201-A9F1-19371E828D9EQ46535634-F3924641-1873-4523-A5C6-83887D52A616Q52897133-6B5CE975-C9AB-4A7E-958A-9C67F07D926F
P2860
Mechanistic pharmacokinetic/pharmacodynamic modeling of in vivo tumor uptake, catabolism, and tumor response of trastuzumab maytansinoid conjugates.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Mechanistic pharmacokinetic/ph ...... zumab maytansinoid conjugates.
@en
type
label
Mechanistic pharmacokinetic/ph ...... zumab maytansinoid conjugates.
@en
prefLabel
Mechanistic pharmacokinetic/ph ...... zumab maytansinoid conjugates.
@en
P2093
P2860
P1476
Mechanistic pharmacokinetic/ph ...... zumab maytansinoid conjugates.
@en
P2093
Carmela A Provenzano
Douglas D Leipold
Elaine Mai
Gail D Lewis Phillips
Hans K Erickson
Holly Johnson
Jay Tibbitts
P2860
P2888
P304
P356
10.1007/S00280-014-2561-2
P577
2014-09-04T00:00:00Z
P6179
1031765944