Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI.

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Determination of the Absolute Configurations of Chiral Drugs Using Chiroptical Spectroscopy Absolute configuration assignment of (+)-fluralaner using vibrational circular dichroism.Ligand efficiency metrics in drug discovery: the pros and cons from a practical perspective.

P2860

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P2860

Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI.

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2016 nî lūn-bûn

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2016年の論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年论文

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2016年论文

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Optimization of Novel Aza-benz ...... ies and Mitigation of CYP TDI.

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Optimization of Novel Aza-benz ...... ies and Mitigation of CYP TDI.

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Optimization of Novel Aza-benz ...... ies and Mitigation of CYP TDI.

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P1476

Optimization of Novel Aza-benz ...... ies and Mitigation of CYP TDI.

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Brian C Magliaro

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Cuyue Tang

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Edward C Sherer

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Hannah D G F Lehman

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Jason M Uslaner

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Joseph E Pero

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Julie A O'Brien

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Kerry L Fillgrove

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Leo A Joyce

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Mark E Layton

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P2860

Schizophrenia, “Just the Facts”: What we know in 2008

Glutamate uptake

Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial

Effectiveness of antipsychotic drugs in patients with chronic schizophrenia

Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2/3) receptor positive allosteric modulators (PAMs): pharmacological characterization and assessment in a rat model of cocaine dependence.

Rapid assessment of a novel series of selective CB(2) agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis.

Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor.

A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models.

Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.

Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice.

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312-317

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10.1021/ACSMEDCHEMLETT.5B00459

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Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI.

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P2860

P2860

Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI.

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