The SIRT1/HIF2α axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy.
about
A roadmap for interpreting (13)C metabolite labeling patterns from cellsRadiosynthesis and validation of (±)-[18F]-3-fluoro-2-hydroxypropionate ([18F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumorsCancer heterogeneity is not compatible with one unique cancer cell metabolic mapHypoxia-inducible factor-2α promotes tumor progression and has crosstalk with Wnt/β-catenin signaling in pancreatic cancerTargeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid TumorsReducing the serine availability complements the inhibition of the glutamine metabolism to block leukemia cell growth.Lactate promotes glutamine uptake and metabolism in oxidative cancer cells.Dlx-2 and glutaminase upregulate epithelial-mesenchymal transition and glycolytic switch.Monocarboxylate transporters in the brain and in cancer.Glutamine activates STAT3 to control cancer cell proliferation independently of glutamine metabolism.Sirtuins and the Metabolic Hurdles in Cancer.NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism.A new ER-specific photosensitizer unravels (1)O2-driven protein oxidation and inhibition of deubiquitinases as a generic mechanism for cancer PDT.Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells.Manipulating Angiogenesis by Targeting Endothelial Metabolism: Hitting the Engine Rather than the Drivers-A New Perspective?Dynamic scenario of metabolic pathway adaptation in tumors and therapeutic approachTumour acidosis: from the passenger to the driver's seat.MBD3 mediates epigenetic regulation on EPAS1 promoter in cancer.Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects.Hypoxia-Inducible Factor 2-Dependent Pathways Driving Von Hippel-Lindau-Deficient Renal Cancer.
P2860
Q27003299-BDA2F57A-22B5-4BEF-AB5F-6B0C23491112Q33648519-598C4F1E-A16A-4A39-A3C4-57DF315A6410Q33721222-B3832892-6FAC-4D68-A40F-BB2A96E390FAQ33908602-0764AA11-2ED9-40A0-8247-871079DE3A29Q35845149-6E9A8C66-CEF3-45D8-BCAA-5DBCB580CAE1Q36738966-1EB159B1-7805-49C5-B05E-7C4A5A404DF5Q36781200-51923F62-202D-4D8F-8DF0-286960098A2CQ36946666-626A6D34-CF69-48B7-B305-40F7BEB428BDQ37187094-9E232216-1804-45B4-A3EB-9057F9757B59Q37594451-A2D59036-9B99-4801-A3E7-576E3E375B85Q38540810-435A04D2-E33C-466E-B739-45FBA52BDEE5Q38667022-F32DFE92-54FC-4FCD-A509-4555D9FD759EQ38810435-4AED39AF-99BC-419D-942A-57057606BA8CQ38866428-0A323B07-DF64-4CCC-93F9-F18E41D88D3FQ38882106-8752E689-BBB3-49E5-91C3-F4AAFE5A7292Q39542687-1650E7E9-F09D-4E82-B119-BE0B42906FA3Q47772621-806CBA63-5C21-40CC-91AA-AA981A6DB607Q51611929-30794005-5C42-462D-A1C6-0BB86B043676Q51735722-03C0E2ED-CC22-42A8-9995-5F3081231E90Q55419613-A71FC488-845C-412D-B79B-040845D59A8C
P2860
The SIRT1/HIF2α axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
2014年學術文章
@zh
2014年學術文章
@zh-hant
name
The SIRT1/HIF2α axis drives re ...... ers tumor response to therapy.
@en
type
label
The SIRT1/HIF2α axis drives re ...... ers tumor response to therapy.
@en
prefLabel
The SIRT1/HIF2α axis drives re ...... ers tumor response to therapy.
@en
P2093
P1433
P1476
The SIRT1/HIF2α axis drives re ...... ters tumor response to therapy
@en
P2093
Adan Pinto
Cyril Corbet
Florence Polet
Nihed Draoui
Xavier Drozak
P304
P356
10.1158/0008-5472.CAN-14-0705
P407
P577
2014-08-01T00:00:00Z