Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins. - Wikidata - awgldk - TriplyDB

Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins.

Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins.

http://www.wikidata.org/entity/Q38993482

about

A Disintegrin and Metalloprotease (ADAM): Historical Overview of Their Functions Notch-Mediated Cell Adhesion Targeting Notch to overcome radiation resistance Turn It Down a Notch Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region A Disintegrin and Metalloproteinase10 (ADAM10) Regulates NOTCH Signaling during Early Retinal Development.Notch signaling promotes osteoclast maturation and resorptive activity.Myeloid DLL4 Does Not Contribute to the Pathogenesis of Non-Alcoholic Steatohepatitis in Ldlr-/- Mice.SheddomeDB: the ectodomain shedding database for membrane-bound shed markers.TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization.ADAM Proteases and Gastrointestinal Function.New insights into the tetraspanin Tspan5 using novel monoclonal antibodies.Characterization of Notch Signaling During Osteogenic Differentiation in Human Osteosarcoma Cell Line MG63.Regulation of A disintegrin and metalloproteinase (ADAM) family sheddases ADAM10 and ADAM17: The emerging role of tetraspanins and rhomboids.Human NOTCH2 Is Resistant to Ligand-independent Activation by Metalloprotease Adam17.Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins.Role of ADAM10 in intestinal crypt homeostasis and tumorigenesis.ADAM10-Dependent Signaling Through Notch1 and Notch4 Controls Development of Organ-Specific Vascular Beds.Decitabine, a DNA-demethylating agent, promotes differentiation via NOTCH1 signaling and alters immune-related pathways in muscle-invasive bladder cancer.The Tetraspanin TSPAN33 Controls TLR-Triggered Macrophage Activation through Modulation of NOTCH Signaling.Blocking 17β-hydroxysteroid dehydrogenase type 1 in endometrial cancer: a potential novel endocrine therapeutic approach.Sustained Notch2 signaling in osteoblasts, but not in osteoclasts, is linked to osteopenia in a mouse model of Hajdu-Cheney syndrome.The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation.NOTCH2-ligand complex is cleaved to produce NEXT2 NEXT2 is cleaved to produce NICD2 Gαi Signaling Promotes Marginal Zone B Cell Development by Enabling Transitional B Cell ADAM10 Expression.NOTCH3-ligand complex is cleaved to produce NEXT3 NOTCH3 Activation and Transmission of Signal to the Nucleus Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC Synergistic Effects of NOTCH/γ-Secretase Inhibition and Standard of Care Treatment Modalities in Non-small Cell Lung Cancer Cells

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P2860

Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins.

http://www.wikidata.org/entity/Q38993482

description

2014 nî lūn-bûn

@nan

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

2014年论文

@zh

2014年论文

@zh-cn

name

Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins.

@en

type

label

Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins.

@en

prefLabel

Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins.

@en

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Molecular and Cellular Biology

P1476

Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins.

@en

P2093

Arjan J Groot

http://www.w3.org/2001/XMLSchema#string

Caroline M Hodin

http://www.w3.org/2001/XMLSchema#string

Jan Theys

http://www.w3.org/2001/XMLSchema#string

Karina Reiss

http://www.w3.org/2001/XMLSchema#string

Marc Vooijs

http://www.w3.org/2001/XMLSchema#string

Paul Saftig

http://www.w3.org/2001/XMLSchema#string

Roger Habets

http://www.w3.org/2001/XMLSchema#string

Sanaz Yahyanejad

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P2860

Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors

NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway

Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss

Mutations in NOTCH1 cause aortic valve disease

TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms

Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2

The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients

Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte migration in cutaneous wound healing

Therapeutic antibody targeting of individual Notch receptors

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2822-2832

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10.1128/MCB.00206-14

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15

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34

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2014-05-19T00:00:00Z

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24842903

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4135574

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