PI3K and Bcl-2 inhibition primes glioblastoma cells to apoptosis through downregulation of Mcl-1 and Phospho-BAD.
about
Recent advances in the use of PI3K inhibitors for glioblastoma multiforme: current preclinical and clinical developmentCombined inhibition of Bcl-2/Bcl-xL and Usp9X/Bag3 overcomes apoptotic resistance in glioblastoma in vitro and in vivo.Emerging targets for glioblastoma stem cell therapyMCL-1-independent mechanisms of synergy between dual PI3K/mTOR and BCL-2 inhibition in diffuse large B cell lymphoma.TIC10/ONC201 synergizes with Bcl-2/Bcl-xL inhibition in glioblastoma by suppression of Mcl-1 and its binding partners in vitro and in vivo.Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family membersDeubiquitylating enzyme USP9x regulates radiosensitivity in glioblastoma cells by Mcl-1-dependent and -independent mechanisms.Inhibition of deubiquitinases primes glioblastoma cells to apoptosis in vitro and in vivo.Metabolic reprogramming of glioblastoma cells by L-asparaginase sensitizes for apoptosis in vitro and in vivoResistance to Cell Death and Its Modulation in Cancer Stem Cells.Targeting intrinsic apoptosis and other forms of cell death by BH3-mimetics in glioblastoma.PARP inhibition restores extrinsic apoptotic sensitivity in glioblastoma.Waltonitone induces apoptosis through mir-663-induced Bcl-2 downregulation in non-small cell lung cancer.Targeting Deubiquitinating Enzymes in Glioblastoma Multiforme: Expectations and Challenges.A Synthetic Cell-Penetrating Dominant-Negative ATF5 Peptide Exerts Anticancer Activity against a Broad Spectrum of Treatment-Resistant Cancers.M011L-deficient oncolytic myxoma virus induces apoptosis in brain tumor-initiating cells and enhances survival in a novel immunocompetent mouse model of glioblastomaMitochondrial matrix chaperone and c-myc inhibition causes enhanced lethality in glioblastoma.BH3-mimetics and BET-inhibitors elicit enhanced lethality in malignant glioma.Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL.Inhibition of Mitochondrial Matrix Chaperones and Antiapoptotic Bcl-2 Family Proteins Empower Antitumor Therapeutic Responses.Glioblastoma and acute myeloid leukemia: malignancies with striking similarities.Multipronged quantitative proteomic analyses indicate modulation of various signal transduction pathways in human meningiomas.The dual PI3K/mTOR inhibitor dactolisib elicits anti-tumor activity in vitro and in vivo.The role of miR-125b-mitochondria-caspase-3 pathway in doxorubicin resistance and therapy in human breast cancer.Inhibition of Bcl-2/Bcl-xL and c-MET causes synthetic lethality in model systems of glioblastoma.
P2860
Q33776641-3C0B3B34-65B1-4CA6-9DB6-153CAE6F65A7Q35987399-0C0A2C2C-F717-4390-8890-0E7B6194DBEDQ36502009-956CA072-753B-4ADD-8A16-32B71712EB9FQ36546300-F79FA4AC-97A4-4B90-8EFC-53578AF21470Q36546689-D2A41E6D-BD41-472F-884C-618720E33A32Q36601134-7BDA6E1E-1250-480A-A4DD-8C27F0ED244BQ36751778-EC2A81E2-7F55-44B7-BA2A-1032B3529708Q37022290-6B01C0FA-3AEB-4618-AD66-153D40F01EC7Q37376084-83E49C6C-0659-4033-9A95-DAE4F15B852BQ37708637-B10BBCB7-5263-4EAF-94AB-EFC42F4BA716Q38677019-672094ED-42E6-4709-B210-70F9F2FD03B1Q38926314-1102D582-F0EB-44F2-AD1C-D99736EC4AABQ38949236-5CBBE158-526F-4C04-8FD5-AB85C7A7535EQ38989377-1C757DA6-7487-46D9-AD20-958D0E01C7ABQ39811568-172715E3-9A3D-4EC3-BFB8-CEBA9B591EBBQ39932965-BEE95057-F4D6-4DE0-B026-D96DFC26D2DCQ41043950-7EF863B3-257F-4C07-BF87-BA2B3C354A8CQ41879630-677360C5-2010-4BC8-B4B3-57214372B67BQ42652909-8BF3908F-77D0-4CFA-AFCB-CC7001A9E13EQ47115416-A39798BD-EA3C-4E30-8EA8-429BEDB840A8Q47339574-936F7C78-224A-4A7B-A57F-F266C736CA60Q48450830-3C18A5EB-54C7-4C4A-A600-AA55B7082BC7Q49349544-7DD58614-0D9B-498B-9E54-BEAE3210BFE9Q53220492-EAC55AA9-4578-4EA6-B5DA-9C654D472D1BQ55263786-F3CBFC3A-2497-4C92-A0A4-6C6208842CAD
P2860
PI3K and Bcl-2 inhibition primes glioblastoma cells to apoptosis through downregulation of Mcl-1 and Phospho-BAD.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
PI3K and Bcl-2 inhibition prim ...... tion of Mcl-1 and Phospho-BAD.
@en
PI3K and Bcl-2 inhibition prim ...... tion of Mcl-1 and Phospho-BAD.
@nl
type
label
PI3K and Bcl-2 inhibition prim ...... tion of Mcl-1 and Phospho-BAD.
@en
PI3K and Bcl-2 inhibition prim ...... tion of Mcl-1 and Phospho-BAD.
@nl
prefLabel
PI3K and Bcl-2 inhibition prim ...... tion of Mcl-1 and Phospho-BAD.
@en
PI3K and Bcl-2 inhibition prim ...... tion of Mcl-1 and Phospho-BAD.
@nl
P2093
P1476
PI3K and Bcl-2 inhibition prim ...... tion of Mcl-1 and Phospho-BAD.
@en
P2093
Alonzo H Ross
David Macleod
Fresia Pareja
John F Crary
Markus D Siegelin
Peter D Canoll
P304
P356
10.1158/1541-7786.MCR-13-0650
P577
2014-04-22T00:00:00Z